Alicolours at 15:35, 21 February 2026

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{{Short description|Indian academic (born 1973)}}
{{about||the Indian painter|Amit Dutt (painter)}}
{{Use dmy dates|date=August 2018}}
{{Use Indian English|date=August 2018}}
{{Infobox scientist
| name = Amit Dutt
| image = Amit Dutt pic.jpg
| alt =
| caption =
| birth_date = {{Birth date and age|df=yes|1973|9|6}}
| birth_place = [[Patna]], India
| death_date =
| death_place =
| fields = {{ublist | [[Cancer genomics]] }}
| workplaces = {{ublist | [[ICGEB]] | [[University of Zurich|Zurich University]] | [[Broad Institute]] | [[Dana–Farber Cancer Institute]] | [[Tata Memorial Centre#ACTREC|ACTREC]] }}
| alma_mater = {{ublist | [[Delhi University]] | [[Jamia Millia Islamia]] | [[International Centre for Genetic Engineering and Biotechnology|ICGEB]] | [[University of Zurich]] }}
| doctoral_advisor = {{ublist | Alex Hajnal (ZU) | Vanga Siva Reddy (DU) | Arif Ali (JMI) }}
| doctoral_students =
| known_for = Studies on [[Fibroblast growth factor receptor]]
| awards = {{ublist| 2017 [[Shanti Swarup Bhatnagar Prize]] | 2023 [[DBT- Tata Innovation Fellowship]] }}
}}
'''Amit Dutt''' (born 6 September 1973) is an Indian scientist, geneticist and the principal investigator at [[Tata Memorial Centre#ACTREC|Advanced Centre for Treatment, Research and Education in Cancer]] (ACTREC) of [[Tata Memorial Centre]]. Known for his studies on [[Fibroblast growth factor receptor]], Dutt is a [[Wellcome Trust]] / [[Department of Biotechnology|DBT India]] Alliance Intermediate Fellow. The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards, for his contributions to medical sciences in 2017.<ref name="View Bhatnagar Awardees">{{Cite web |url=http://ssbprize.gov.in/Content/Detail.aspx?AID=535 |title=View Bhatnagar Awardees |date=2017-11-11 |publisher=Shanti Swarup Bhatnagar Prize |access-date=2017-11-11}}</ref>{{Refn|group=note|Long link - please select award year to see details}}

== Biography ==
[[File:Delhiuni.jpg|thumb|left|Delhi University]]
Amit Dutt, born on 6 September 1973 in Patna, capital of the Indian state of Bihar, earned a BSc in botany from Desbandhu College, Delhi University in 1994 and continued there to complete a post-graduate diploma in Biochemical Technology in 1995 from the Sri Venkateswara College.<ref name="Biographical Information - Amit Dutt">{{Cite web |url=http://www.actrec.gov.in/pi-webpages/AmitDutt/images1/Amit_Dutt_CV_20170904_website.pdf |title=Biographical Information - Amit Dutt |date=2017-11-03 |website=ACTREC |access-date=2017-11-03 |archive-url=https://web.archive.org/web/20171107020214/http://www.actrec.gov.in/pi-webpages/AmitDutt/images1/Amit_Dutt_CV_20170904_website.pdf |archive-date=7 November 2017 }}</ref>{{Refn|group=note|Curriculum vitae available in downloadable format}} Moving to [[Jamia Millia Islamia]], he obtained his MSc in 1997 and enrolled for doctoral studies at the Delhi center of the [[International Centre for Genetic Engineering and Biotechnology]] to secure a PhD in plant genetics in 2000, guided by Vanga Siva Reddy of Delhi University and Arif Ali of Jamia Millia Islamia.<ref name="Dr. Amit Dutt-Biography">{{Cite web |url=http://www.actrec.gov.in/pi-webpages/AmitDutt/dutt_biography.html |title=Dr. Amit Dutt-Biography |date=2017-11-05 |website=ACTREC |access-date=2017-11-05 |archive-date=7 November 2017 |archive-url=https://web.archive.org/web/20171107023402/http://www.actrec.gov.in/pi-webpages/AmitDutt/dutt_biography.html }}</ref> Subsequently, he traveled to the [[University of Zurich]] and working under the guidance of Alex Hajnal at the Institute of Molecular Life Sciences of the university, secured another PhD in [[Developmental Biology]] in 2004.<ref name="About Fellow-Dutt">{{Cite web |url=http://www.wellcomedbt.org/fellowsprofile/dr-amit-dutt-151 |title=About Fellow-Dutt |date=2017-11-05 |website=Wellcome-DBT |access-date=2017-11-05}}</ref><ref name="Amit Dutt, B.Sc, Ph.D., Ph.D. Principal Investigator">{{Cite web |url=http://www.incredb.org/investigator.php?incredb_id=437 |title=Amit Dutt, B.Sc, Ph.D., Ph.D. Principal Investigator |date=2017-11-05 |website=India Cancer Research Database |access-date=2017-11-05}}</ref>

Dutt continued in Zurich to work at the Institute of Neuropathology of the university and in 2005, he moved to join the laboratory of Matthew Meyerson at the [[Broad Institute|Broad Institute of Harvard and MIT]] as a research associate and worked there till 2010, stationing at [[Dana–Farber Cancer Institute]], a [[Harvard Medical School]] affiliate.<ref name="Biographical Information - Amit Dutt" /> On his return to India in Oct 2010, he joined [[Tata Memorial Centre]], at the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), [[Navi Mumbai]] where he is the principal investigator at scientist (grade F) and heads the Integrated Cancer Genomics Lab, popularly known as Dutt Lab.<ref name="Integrated Cancer Genomics Lab">{{Cite web |url=http://www.actrec.gov.in/pi-webpages/AmitDutt/dutt_index.html |title=Integrated Cancer Genomics Lab |date=2017-11-05 |website=ACTREC |access-date=2017-11-05 |archive-date=7 November 2017 |archive-url=https://web.archive.org/web/20171107011824/http://www.actrec.gov.in/pi-webpages/AmitDutt/dutt_index.html }}</ref>

== Legacy and honors ==
[[File:Protein MMP10 PDB 1q3a.png|thumb|235px|Protein MMP10 PDB 1q3a]]
Dutt is known to have made notable contributions in the field of cancer genetics,<ref name="Brief Profile of the Awardee">{{Cite web |url=http://ssbprize.gov.in/Content/Detail.aspx?AID=532 |title=Brief Profile of the Awardee |date=2017-10-21 |publisher=Shanti Swarup Bhatnagar Prize |access-date=2017-10-21}}</ref> widening our understanding of the disease and its translational possibilities.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{Cite web |url=http://www.csirhrdg.res.in/ssb.pdf |title=Handbook of Shanti Swarup Bhatnagar Prize Winners |date=2017-10-17 |publisher=Council of Scientific and Industrial Research |access-date=2017-10-17 |archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf |archive-date=4 March 2016 }}</ref> The group led by him have been engaged in the study of the progression of cancer in the lung, breast, cervical, gallbladder, head and neck and his research may be classified under three heads; [[cancer genomics]], [[functional genomics]] and pathogen discovery.<ref name="Integrated Cancer Genomics Lab" /> It is reported that the research collaboration Dutt had with Kumar Prabhash of [[Tata Memorial Centre]] led to the Epidermal Growth Factor Receptor (EGFR) and KRAS mutation profiling of Indian lung cancer patients for the first time.<ref name="It's a Moment of Pride for Jamia Millia">{{Cite web |url=http://www.okhlatimes.com/pride-jamia/13505/ |title=It's a Moment of Pride for Jamia Millia |date=1 October 2017 |website=Okhla Times |access-date=2017-11-05}}</ref> The research association between the duo has also led to the development of ''HPVDetector'' and ''TMC-SNPdb'' (both computational tools) and ''CRE'', an experimental tool.<ref name="About Fellow-Dutt" /> Discovery of [[MMP10]] protein, a [[biomarker]] which assists the doctors in deciding the surgical protocol in tongue cancer patients is another contribution of Dutt, which was the result of collaborative research with Sudhir Nair of TMC.<ref name="Biomarker tells of tongue cancer spread">{{Cite news |url=http://www.thehindu.com/sci-tech/health/biomarker-tells-of-tongue-cancer-spread/article19547502.ece |title=Biomarker tells of tongue cancer spread |date=23 August 2017 |website=The Hindu |access-date=2017-11-05|last1=Prasad |first1=R. }}</ref> They also identified a [[genome]] signature which associated tobacco chewing with oral cancer. His studies have been documented by way of a number of articles<ref name="On Google Scholar">{{Cite web |url=https://scholar.google.co.in/citations?user=0nP8HVYAAAAJ&hl=en |title=On Google Scholar |date=2017-10-17 |publisher=Google Scholar |access-date=2017-10-17}}</ref> and [[ResearchGate]], an online article repository of scientific articles, has listed 118 of them.<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/profile/Amit_Dutt2 |title=On ResearchGate |date=2017-10-17 |access-date=2017-10-17}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}}

Dutt is a member of faculty of [[F1000 Prime]] and holds memberships in associations such as [[American Association for Cancer Research]], the Indian chapter of Lung Cancer Consortium of Asia, Society of Biological Chemists (India), and Indian Association for Cancer Research.<ref name="F1000 Prime faculty">{{Cite web |url=https://f1000.com/prime/thefaculty/member/1573032911635882 |title=F1000 Prime faculty |date=2017-11-05 |website=F1000 Prime |access-date=2017-11-05}}</ref> He has also sat in the editorial boards of [[BMC Genomics]] and [[PLoS One]] journals.<ref name="It's a Moment of Pride for Jamia Millia" />

== Awards and honors ==
Apart from a number of student fellowships, Dutt has held research fellowships, starting with the Julius Klaus Foundation Fellowship in 2004, followed by Swiss National Science Foundation Postdoctoral fellowship of the Government of Switzerland in 2005.<ref name="Biographical Information - Amit Dutt" /> The [[Department of Biotechnology]] awarded him the Ramalingaswamy Fellowship in 2010<ref name="It's a Moment of Pride for Jamia Millia" /><ref name="List of Fellows">{{Cite web |url=https://ramalingaswami.wordpress.com/list-of-fellows/ |title=List of Fellows |date=2017-11-06 |website=Ramalingaswami Fellows |access-date=2017-11-06}}</ref> and he became a [[Wellcome Trust]] / DBT India Alliance Intermediate Fellow in 2011.<ref name="About Fellow-Dutt" /> The Council of Scientific and Industrial Research awarded Dutt the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards in 2017.<ref name="10 scientists receive Shanti Swarup Bhatnagar Prize">{{Cite news |url=http://www.thehindu.com/news/national/10-scientists-receive-shanti-swarup-bhatnagar-prize/article19758442.ece |title=10 scientists receive Shanti Swarup Bhatnagar Prize |date=26 September 2017 |work=The Hindu |access-date=2017-11-11}}</ref> The following year he was recognized on the [[Asian Scientist 100]].

== Selected bibliography ==
*{{Cite journal |vauthors=Godbole M, Chandrani P, Gardi N, Dhamne H, Patel K, Yadav N, Gupta S, Badwe R, Dutt A|title=miR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells |journal=Cancer Biol Ther |publication-date=2017 |volume=18 |issue=10 |pages=801–805 |doi=10.1080/15384047.2017.1373216|pmid=28876975 |pmc=5678702 |year=2017 }}
*{{Cite journal |vauthors=Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, Arora P, Bal M, Nair S, Dutt A|title=Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases|journal=Oral Oncol. |publication-date=2017 |volume=73 |pages=56–64 |doi=10.1016/j.oraloncology.2017.08.003|pmid=28939077|pmc=5628952|year=2017}}
*{{Cite journal |vauthors=Godbole M, Tiwary K, Badwe R, Gupta S, Dutt A|title=Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report |journal=Cell Oncol (Dordr) |publication-date=2017 |volume=40 |issue=4 |pages=411–417 |doi=10.1007/s13402-017-0330-z|year=2017 |pmc=5537311 |pmid=28653288}}
*{{Cite journal |vauthors=Chandrani P, Prabhash K, Prasad R, Sethunath V, Ranjan M, Iyer P, Aich J, Dhamne H, Iyer DN, Upadhyay P, Mohanty B, Chandna P, Kumar R, Joshi A, Noronha V, Patil V, Ramaswamy A, Karpe A, Thorat R, Chaudhari P, Ingle A, Choughule A, Dutt A|title=Drug-sensitive FGFR3 mutations in lung adenocarcinoma |journal=Ann. Oncol. |publication-date=2017 |volume=28 |issue=3 |pages=597–603 |doi=10.1093/annonc/mdw636|pmid=27998968 |pmc=5391708 |year=2016 }}
*{{Cite journal |vauthors=Mittra I, Samant U, Sharma S, Raghuram GV, Saha T, Tidke P, Pancholi N, Gupta D, Prasannan P, Gaikwad A, Gardi N, Chaubal R, Upadhyay P, Pal K, Rane B, Shaikh A, Salunkhe S, Dutt S, Mishra PK, Khare NK, Nair NK, Dutt A|title=Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells toinduce DNA damage and inflammation |journal=Cell Death Discovery |publication-date=2017 |volume=3 |page=17015 |doi=10.1038/cddiscovery.2017.15|pmid=28580170 |pmc=5447133 |year=2017 }}
*{{Cite journal |vauthors=Rekhi B, Upadhyay P, Ramteke MP, Dutt A|title=MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes |journal=Mod. Pathol. |publication-date=2016 |volume=29|issue=12 |pages=1532–1540 |doi=10.1038/modpathol.2016.144|pmid=27562493 |pmc=5133269 |year=2016 }}
*{{Cite journal |vauthors=Upadhyay P, Nair S, Kaur E, Aich J, Dani P, Sethunath V, Gardi N, Chandrani P, Godbole M, Sonawane K, Prasad R, Kannan S, Agarwal B, Kane S, Gupta S, Dutt S, Dutt A|title=Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer |journal=Oncotarget |publication-date=2016 |volume=7 |issue=31 |pages=50437–50449 |doi=10.18632/oncotarget.10419|pmid=27391340 |pmc=5226594 |year=2016 }}
*{{Cite journal |vauthors=Upadhyay P, Gardi N, Desai S, Sahoo B, Singh A, Togar T, Iyer P, Prasad R, Chandrani P, Gupta S, Dutt A|title=TMC-SNPdb: an Indian germline variant database derived from whole exome sequences |journal=Database |volume=2016 |article-number=baw104 |publication-date=2016 |doi=10.1093/database/baw104|pmid=27402678 |pmc=4940432 |year=2016 }} }
*{{Cite journal |vauthors=Iyer P, Barreto SG, Sahoo B, Chandrani P, Ramadwar MR, Shrikhande SV, Dutt A|title=Non-typhoidal Salmonella DNA traces in gallbladder cancer |journal=Infect Agents Cancer |publication-date=2016 |volume=11 |page=12 |doi=10.1186/s13027-016-0057-x|pmid=26941832 |pmc=4776363 |year=2016 |doi-access=free }}
*{{Cite journal |vauthors=Chandrani P, Upadhyay P, Iyer P, Tanna M, Shetty M, Raghuram GV, Oak N, Singh A, Chaubal R, Ramteke M, Gupta S, Dutt A|title=Integrated genomics approach to identify biologically relevant alterations in fewer samples |journal=BMC Genomics |publication-date=2015 |volume=16 |page=936 |doi=10.1186/s12864-015-2138-4|pmid=26572163 |pmc=4647579 |year=2015 |doi-access=free }}
*{{Cite journal |vauthors=Chandrani P, Kulkarni V, Iyer P, Upadhyay P, Chaubal R, Das P, Mulherkar R, Singh R, Dutt A|title=NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome |journal=Br J Cancer |publication-date=2015 |volume=112 |issue=12 |pages=1958–65 |doi=10.1038/bjc.2015.121|pmid=25973533 |pmc=4580395 |year=2015 }}
* {{Cite journal |vauthors=Choughule A, Sharma R, Trivedi V, Thavamani A, Noronha V, Joshi A, Desai S, Chandrani P, Sundaram P, Utture S, Jambhekar N, Gupta S, Aich J, Prabhash K, Dutt A|title=Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer |journal=Br J Cancer |publication-date=2014 |volume=111 |issue=11 |pages=2203–4 |doi=10.1038/bjc.2014.401|pmid=25117816 |pmc=4260019 |year=2014 }}
*{{Cite journal |vauthors=Barreto SG, Dutt A, Chaudhary A|title=A genetic model for gallbladder carcinogenesis and its dissemination |journal=Ann. Oncol. |publication-date=2014 |volume=25 |issue=6 |pages=1086–97|doi=10.1093/annonc/mdu006|pmid=24705974 |pmc=4037856 |year=2014 }}
*{{Cite journal |vauthors=Chougule A, Prabhash K, Noronha V, Joshi A, Thavamani A, Chandrani P, Upadhyay P, Utture S, Desai S, Jambhekar N, Dutt A|title=Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity |journal=PLOS ONE |publication-date=2013 |volume=8 |issue=10 |article-number=e76164 |doi=10.1371/journal.pone.0076164 |pmid=24124538 |pmc=3790706 |year=2013 |bibcode=2013PLoSO...876164C |doi-access=free }}
*{{Cite journal |vauthors=Noronha V, Prabhash K, Thavamani A, Chougule A, Purandare N, Joshi A, Sharma R, Desai S, Jambekar N, Dutt A, Mulherkar R |title=EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy |journal=PLOS ONE |publication-date=2013 |volume=8 |issue=4 |article-number=e61561 |doi=10.1371/journal.pone.0061561 |pmid=23620765 |pmc=3631198 |year=2013 |bibcode=2013PLoSO...861561N |doi-access=free }}
*{{Cite journal |vauthors=Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H, Gray NS, Meyerson M|title=Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer |journal=PLOS ONE |publication-date=2011 |volume=6 |issue=6 |article-number=e20351 |doi=10.1371/journal.pone.0020351 |pmid=21666749 |pmc=3110189 |year=2011 |bibcode=2011PLoSO...620351D |doi-access=free }}
* {{Cite journal |vauthors=Dutt A, Salvesen HB, Greulich H, Sellers WR, Beroukhim R, Meyerson M |title=Somatic mutations are present in all members of the AKT family in endometrial carcinoma |journal=Br J Cancer |publication-date=2009 |volume=101 |issue=7|pages=1218–9 |doi=10.1038/sj.bjc.6605301|year=2009 |pmc=2768084 |pmid=19738612}}
*{{Cite journal |vauthors=Dutt A, Salvesen HB, Chen TH, Ramos AH, Onofrio RC, Hatton C, Nicoletti R, Winckler W, Grewal R, Hanna M, Wyhs N, Ziaugra L, Richter DJ, Trovik J, Engelsen IB, Stefansson IM, Fennell T, Cibulskis K, Zody MC, Akslen LA, Gabriel S, Wong KK, Sellers WR, Meyerson M, Greulich H|title=Drug-sensitive FGFR2 mutations in endometrial carcinoma |journal=Proc Natl Acad Sci U S A |publication-date=2008 |volume=105 |issue=25 |pages=8713–7 |doi=10.1073/pnas.0803379105 |pmid=18552176 |pmc=2438391 |year=2008 |bibcode=2008PNAS..105.8713D |doi-access=free }}
* {{Cite journal |vauthors=Dutt A, Canevascini S, Froehli-Hoier E, Hajnal A|title=EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid |journal=PLOS Biol. |publication-date=2004 |volume=2 |issue=11 |article-number=e334 |doi=10.1371/journal.pbio.0020334 |pmid=15455032 |pmc=519001 |year=2004 |doi-access=free }}

== See also ==
{{Div col|colwidth=30em}}
* [[Carcinogenesis]]
* [[Matrix metalloproteinase]]
{{div col end}}
{{portal|India|Medicine}}

== Notes ==
{{reflist|group=note|2}}

== References ==
{{reflist}}

== Further reading ==
* {{Cite web |url=http://www.wellcomedbt.org/fellowsprofile/main/research/id/151 |title=Amit Dutt - Research Summary |date=2017-11-05 |website=Wellcome Trust - DBT India Alliance |access-date=2017-11-05}}

== External links ==
* {{Cite web |url=https://www.ncbi.nlm.nih.gov/myncbi/amit.dutt.2/bibliography/public/?sortby=pubDate&sdirection=descending |title=Amit Dutt on PubMed |date=2017-11-05 |website=PubMed |access-date=2017-11-05}}

{{SSBPST recipients in Medical Science}}

{{authority control}}

{{DEFAULTSORT:Dutt, Amit}}
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Medical Science]]
[[Category:Indian medical academics]]
[[Category:1973 births]]
[[Category:Living people]]
[[Category:Scientists from Bihar]]
[[Category:Delhi University alumni]]
[[Category:Jamia Millia Islamia alumni]]
[[Category:University of Zurich alumni]]
[[Category:Academic staff of the University of Zurich]]
[[Category:Indian geneticists]]

Amit Dutt - Revision history

Alicolours at 15:35, 21 February 2026