>Tayi Arajakate at 00:54, 6 July 2021

2021-07-06T00:54:46Z

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{{short description|Indian biotechnology company and vaccine manufacturer}}
{{Use dmy dates|date=July 2020}}
{{Use Indian English|date=July 2020}}
{{Infobox company
| name = Bharat Biotech International Limited
| logo = Bharat Biotech logo.svg
| logo_size = 250px
| logo_caption = Lead Innovation
| type = [[Private Limited Company]]
| industry = [[Biotechnology]]
| foundation = {{Start date and age|1996|p=y}}
| founder = [[Krishna Ella]]
| location = [[Genome Valley]], [[Turakapally]], [[Hyderabad]]
| area_served = Worldwide
| key_people = [[Krishna Ella]]<br />([[Chairman]] & [[Managing director|MD]])
| products = {{hlist|
| ROTAVAC,<ref>{{cite web |title=WHO prequalifies new rotavirus vaccine |url=https://www.who.int/medicines/news/2018/prequalified_new-rotavirus_vaccine/en/ |website=WHO |access-date=2 July 2020 |archive-date=17 July 2020 |archive-url=https://web.archive.org/web/20200717093111/https://www.who.int/medicines/news/2018/prequalified_new-rotavirus_vaccine/en/ |url-status=live }}</ref>
| TypbarTCV,<ref>{{cite web |title=WHO recommends use of first typhoid conjugate vaccine |url=https://www.who.int/immunization/newsroom/press/who_recommends_use_first_typhoid_conjugate_vaccine/en/ |website=WHO |access-date=2 July 2020 |archive-date=7 September 2018 |archive-url=https://web.archive.org/web/20180907105635/http://www.who.int/immunization/newsroom/press/who_recommends_use_first_typhoid_conjugate_vaccine/en/ |url-status=live }}</ref>
| Biopolio
| Comvac |JENVAC | [[COVAXIN]]}}
| num_employees =
| parent =
| subsid = Chiron Behring Vaccines <ref>{{Cite web|last=Bureau|first=Our|title=Bharat Biotech buys Chiron Behring Vaccines from GSK|url=https://www.thehindubusinessline.com/companies/bharat-biotech-buys-chiron-behring-vaccines-from-gsk/article26279438.ece|access-date=2020-07-01|website=The Hindu BusinessLine|language=en|archive-date=31 August 2020|archive-url=https://web.archive.org/web/20200831011034/https://www.thehindubusinessline.com/companies/bharat-biotech-buys-chiron-behring-vaccines-from-gsk/article26279438.ece|url-status=live}}</ref>
| homepage = {{url|https://www.bharatbiotech.com/}}
| footnotes =
}}

'''Bharat Biotech International Limited (BBIL)''' is an [[India|Indian multinational]] [[biotechnology]] company headquartered in [[Hyderabad]], engaged in the [[drug discovery]], [[drug development]], manufacture of [[vaccines]], bio-therapeutics, [[pharmaceuticals]] and [[health care]] products.<ref name="bloomberg">{{cite web |title=Bharat Biotech International Ltd |url=https://www.bloomberg.com/profile/company/7535940Z:IN |website=www.bloomberg.com |access-date=3 July 2020 |archive-date=16 November 2020 |archive-url=https://web.archive.org/web/20201116094545/https://www.bloomberg.com/profile/company/7535940Z:IN |url-status=live }}</ref>

==Overview==
Bharat Biotech has its manufacturing facility situated at [[Genome Valley]], [[Hyderabad]], India.<ref name="bloomberg" /> As of July 2020, the company has over 700 employees<ref name="a">{{cite web |title=Leading Biotech Vaccine Manufacturers in India - Bharat Biotech |url=https://www.bharatbiotech.com/overview.html |website=www.bharatbiotech.com |access-date=30 June 2020 |archive-date=5 July 2020 |archive-url=https://web.archive.org/web/20200705075428/https://bharatbiotech.com/overview.html |url-status=live }}</ref> and has a presence worldwide.<ref name="bloomberg" />

The company has been responsible for developing an eco-friendly recombinant<ref>{{cite web |title=Process for the preparation and purification of recombinant proteins |url=https://patents.google.com/patent/US8956812B2/en |website=patents.google.com |publisher=US patent No US8956812B2 |language=en |date=23 August 2004 |access-date=30 June 2020 |archive-date=9 May 2021 |archive-url=https://web.archive.org/web/20210509101546/https://patents.google.com/patent/US8956812B2/en |url-status=live }}</ref> and a naturally attenuated strain derived Rotavirus vaccine called ROTAVAC.<ref>{{cite journal |last1=Bhandari |first1=Nita |last2=Rongsen-Chandola |first2=Temsunaro |last3=Bavdekar |first3=Ashish |last4=John |first4=Jacob |last5=Antony |first5=Kalpana |last6=Taneja |first6=Sunita |last7=Goyal |first7=Nidhi |last8=Kawade |first8=Anand |last9=Kang |first9=Gagandeep |last10=Rathore |first10=Sudeep Singh |last11=Juvekar |first11=Sanjay |last12=Muliyil |first12=Jayaprakash |last13=Arya |first13=Alok |last14=Shaikh |first14=Hanif |last15=Abraham |first15=Vinod |last16=Vrati |first16=Sudhanshu |last17=Proschan |first17=Michael |last18=Kohberger |first18=Robert |last19=Thiry |first19=Georges |last20=Glass |first20=Roger |last21=Greenberg |first21=Harry B |last22=Curlin |first22=George |last23=Mohan |first23=Krishna |last24=Harshavardhan |first24=G V J A |last25=Prasad |first25=Sai |last26=Rao |first26=T S |last27=Boslego |first27=John |last28=Bhan |first28=Maharaj Kishan |title=Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian infants: a randomised, double-blind, placebo-controlled trial |journal=The Lancet |date=June 2014 |volume=383 |issue=9935 |pages=2136–2143 |doi=10.1016/S0140-6736(13)62630-6 |pmid=24629994|pmc=4532697 }}</ref><ref>{{cite journal |last1=Kang |first1=G |title=Rotavirus vaccines. |journal=Indian Journal of Medical Microbiology |date=October 2006 |volume=24 |issue=4 |pages=252–7 |doi=10.4103/0255-0857.29382 |pmid=17185842|pmc=2481304 }}</ref> They were one of the first to develop vaccines for viral diseases like [[Chikungunya]]<ref>{{cite news |title=Bharat Biotech's Zika, Chikungunya vaccines to enter Phase II trials; focus now on private label market |url=https://www.moneycontrol.com/news/business/companies/bharat-biotechs-zika-chikungunya-vaccines-to-enter-phase-ii-trials-focus-now-on-private-label-market-3633391.html |work=Moneycontrol |access-date=30 June 2020 |archive-date=30 June 2020 |archive-url=https://web.archive.org/web/20200630223427/https://www.moneycontrol.com/news/business/companies/bharat-biotechs-zika-chikungunya-vaccines-to-enter-phase-ii-trials-focus-now-on-private-label-market-3633391.html |url-status=live }}</ref><ref>{{cite news |title=CEPI, 치쿤구니아 백신 개발 위해 국제백신연구소-바라트 바이오텍 컨소시엄에 최대 1410만달러 지원 |url=https://www.newswire.co.kr/newsRead.php?no=905832 |work=CEPI, 치쿤구니아 백신 개발 위해 국제백신연구소-바라트 바이오텍 컨소시엄에 최대 1410만달러 지원 - 뉴스와이어 |date=3 June 2020 |language=ko}}</ref> and [[Zika fever|Zika]].<ref>{{cite news |title=Bharat Biotech gets breakthrough in developing Zika vaccine |url=https://economictimes.indiatimes.com/industry/healthcare/biotech/pharmaceuticals/bharat-biotech-gets-breakthrough-in-developing-zika-vaccine/articleshow/50835450.cms?from=mdr |work=The Economic Times |date=4 February 2016 |access-date=30 June 2020 |archive-date=9 May 2021 |archive-url=https://web.archive.org/web/20210509101526/https://economictimes.indiatimes.com/industry/healthcare/biotech/pharmaceuticals/bharat-biotech-gets-breakthrough-in-developing-zika-vaccine/articleshow/50835450.cms?from=mdr |url-status=live }}</ref><ref>{{cite web |title=CEPI awards up to US$14.1million to consortium of IVI and Bharat Biotech to advance development of Chikungunya vaccine in collaboration with Ind-CEPI – IVI |url=https://www.ivi.int/cepi-awards-up-to-us14-1million-to-consortium-of-ivi-and-bharat-biotech-to-advance-development-of-chikungunya-vaccine-in-collaboration-with-ind-cepi/ |website=www.ivi.int |publisher=International Vaccine Institute |access-date=30 June 2020 |archive-date=24 September 2020 |archive-url=https://web.archive.org/web/20200924214649/https://www.ivi.int/cepi-awards-up-to-us14-1million-to-consortium-of-ivi-and-bharat-biotech-to-advance-development-of-chikungunya-vaccine-in-collaboration-with-ind-cepi/ |url-status=live }}</ref> The company also produces vaccines for [[Japanese Encephalitis]].<ref>{{cite journal |last1=Singh |first1=Anit |last2=Mitra |first2=Monjori |last3=Sampath |first3=Gadey |last4=Venugopal |first4=P. |last5=Rao |first5=J. Venkateswara |last6=Krishnamurthy |first6=B. |last7=Gupta |first7=Mukesh Kumar |last8=Sri Krishna |first8=S. |last9=Sudhakar |first9=B. |last10=Rao |first10=N. Bhuvaneswara |last11=Kaushik |first11=Yashpal |last12=Gopinathan |first12=K. |last13=Hegde |first13=Nagendra R. |last14=Gore |first14=Milind M. |last15=Krishna Mohan |first15=V. |last16=Ella |first16=Krishna M. |title=A Japanese Encephalitis Vaccine From India Induces Durable and Cross-protective Immunity Against Temporally and Spatially Wide-ranging Global Field Strains |journal=Journal of Infectious Diseases |date=1 September 2015 |volume=212 |issue=5 |pages=715–725 |doi=10.1093/infdis/jiv023|pmid=25601942 |doi-access=free }}</ref> Bharat Biotech has [[Biosafety level|biosafety level 3]] (BSL3) laboratories.<ref>{{Cite web|date=17 May 2021|title=Slow off the starting blocks for Bharat Biotech's Covaxin mass production|url=https://www.newindianexpress.com/nation/2021/may/17/slow-off-the-starting-blocks-for-bharat-biotechscovaxin-mass-production-2303416.html|url-status=live|access-date=2021-06-04|website=The New Indian Express}}</ref>

==COVID-19 vaccine development==
{{see also|Covaxin|BBV154|COVID-19 vaccine}}

In April 2020, the company announced that they have partnered with US-based company FluGen and [[University of Wisconsin-Madison]] to develop a COVID-19 vaccine.<ref>{{cite web |title=UW-Madison, Flugen, Bharat Biotech to develop coroflu, a coronavirus vaccine |url=https://ghi.wisc.edu/uw-madison-flugen-bharat-biotech-to-develop-coroflu-a-coronavirus-vaccine/ |website=Global Health Institute |access-date=30 June 2020 |archive-date=10 February 2021 |archive-url=https://web.archive.org/web/20210210135626/https://ghi.wisc.edu/uw-madison-flugen-bharat-biotech-to-develop-coroflu-a-coronavirus-vaccine/ |url-status=live }}</ref><ref>{{cite news |title=Bharat Biotech ties up with US varsity for Covid vaccine |url=https://www.hindustantimes.com/india-news/bharat-biotech-ties-up-with-us-varsity-for-covid-vaccine/story-dyJPOzW2G2rXcwsa9XV3tL.html |work=Hindustan Times |date=20 May 2020 |language=en |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503092950/https://www.hindustantimes.com/india-news/bharat-biotech-ties-up-with-us-varsity-for-covid-vaccine/story-dyJPOzW2G2rXcwsa9XV3tL.html |url-status=live }}</ref>
[[File:Covaxin.jpg|thumb|A 5ml vial of Covaxin]]
In May 2020, Indian Council of Medical Research's ([[ICMR]]'s) [[National Institute of Virology]] approved and provided the virus strains for developing a fully indigenous [[COVID-19]] vaccine.<ref>{{cite news |title=ICMR teams up with Bharat Biotech to develop Covid-19 vaccine |url=https://www.livemint.com/news/india/icmr-teams-up-with-bharat-biotech-to-develop-covid-19-vaccine-11589038719666.html |work=Livemint |date=9 May 2020 |language=en |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503071056/https://www.livemint.com/news/india/icmr-teams-up-with-bharat-biotech-to-develop-covid-19-vaccine-11589038719666.html |url-status=live }}</ref><ref>{{cite news |last1=Chakrabarti |first1=Angana |title=India to develop 'fully indigenous' Covid vaccine as ICMR partners with Bharat Biotech |url=https://theprint.in/health/india-to-develop-fully-indigenous-covid-vaccine-as-icmr-partners-with-bharat-biotech/418180/ |work=ThePrint |date=10 May 2020 |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503084559/https://theprint.in/health/india-to-develop-fully-indigenous-covid-vaccine-as-icmr-partners-with-bharat-biotech/418180/ |url-status=live }}</ref> On June 29, 2020, the company got permission to conduct Phase 1 and Phase 2 [[clinical trials in India]] for a developmental [[COVID-19]] vaccine named '''[[Covaxin]]''', from the Drugs Controller General of India ([[DCGI]]), [[Government of India]].<ref>{{cite news |title=India's First COVID-19 Vaccine Candidate Approved for Human Trials |url=https://www.nytimes.com/reuters/2020/06/29/world/asia/29reuters-health-coronavirus-india-vaccine.html |work=The New York Times |date=29 June 2020 |access-date=30 June 2020 |archive-date=13 February 2021 |archive-url=https://web.archive.org/web/20210213041617/https://www.nytimes.com/reuters/2020/06/29/world/asia/29reuters-health-coronavirus-india-vaccine.html |url-status=live }}</ref><ref>{{cite news |title=Human trial of India coronavirus vaccine announced |url=https://www.bbc.com/news/world-asia-india-53230607 |work=BBC News |date=30 June 2020 |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503140832/https://www.bbc.com/news/world-asia-india-53230607 |url-status=live }}</ref><ref>{{cite news |title=Bharat Biotech's Covid vaccine 1st in India to get approval for human trials |url=https://indianexpress.com/article/india/bharat-biotechs-covid-vaccine-1st-in-india-to-get-approval-for-human-trials-6482403/ |work=The Indian Express |date=30 June 2020 |language=en |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503123154/https://indianexpress.com/article/india/bharat-biotechs-covid-vaccine-1st-in-india-to-get-approval-for-human-trials-6482403/ |url-status=live }}</ref><ref>{{cite news |title=Covaxin: India's first COVID19 vaccine candidate from Bharat Biotech to begin human trials; check details |url=https://www.financialexpress.com/lifestyle/health/covaxin-bharat-biotech-coronavirus-vaccine-india-first-covid19-vaccine-latest-updates/2008500/ |work=The Financial Express |date=30 June 2020 |access-date=30 June 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503110420/https://www.financialexpress.com/lifestyle/health/covaxin-bharat-biotech-coronavirus-vaccine-india-first-covid19-vaccine-latest-updates/2008500/ |url-status=live }}</ref> The Central Drugs Laboratory (CDL) at Kasauli in Himachal Pradesh has been engaged in testing experimental batches of Bharat Biotech's COVID-19 vaccine Covaxin on a priority basis.<ref>{{cite news |title=Bharat Biotech COVID-19 vaccine: Testing underway at CDL-Kasauli, volunteer enrolment begins |url=https://www.moneycontrol.com/news/trends/health-trends/bharat-biotech-covid-19-vaccine-testing-underway-at-cdl-kasauli-volunteer-enrolment-begins-5529041.html |work=Moneycontrol |access-date=10 July 2020 |archive-date=10 July 2020 |archive-url=https://web.archive.org/web/20200710182158/https://www.moneycontrol.com/news/trends/health-trends/bharat-biotech-covid-19-vaccine-testing-underway-at-cdl-kasauli-volunteer-enrolment-begins-5529041.html |url-status=live }}</ref> A total of 12 sites were selected by the [[Indian Council for Medical Research]] for Phase I and II randomised, double-blind and placebo-controlled clinical trials of vaccine candidate.<ref>{{cite news |title=Human clinical trials of potential Covid-19 vaccine 'COVAXIN' started at AIIMS |url=http://ddnews.gov.in/health/human-clinical-trials-potential-covid-19-vaccine-%E2%80%98covaxin%E2%80%99-started-aiims |work=DD News |publisher=Prasar Bharati, Ministry of I & B, Government of India |date=25 July 2020 |access-date=7 August 2020 |archive-date=24 January 2021 |archive-url=https://web.archive.org/web/20210124153146/http://ddnews.gov.in/health/human-clinical-trials-potential-covid-19-vaccine-%E2%80%98covaxin%E2%80%99-started-aiims |url-status=live }}</ref><ref>{{cite news |title=Delhi: 30-year-old is first to get dose of trial drug Covaxin |url=https://indianexpress.com/article/india/aiims-administers-first-dose-of-bharat-biotechs-potential-covid-vaccine-to-30-yr-old-man-6521778/ |work=The Indian Express |date=25 July 2020 |language=en |access-date=7 August 2020 |archive-date=16 March 2021 |archive-url=https://web.archive.org/web/20210316225319/https://indianexpress.com/article/india/aiims-administers-first-dose-of-bharat-biotechs-potential-covid-vaccine-to-30-yr-old-man-6521778/ |url-status=live }}</ref>

In September 2020, the company announced that it was going to manufacture the novel ''chimp-adenovirus'', a single dose [[Nasal administration|intranasal]] vaccine (codenamed [[BBV154]]) for [[COVID-19]] being developed in collaboration with the [[Washington University School of Medicine]] in [[St Louis]], [[Missouri]]. It is currently undergoing clinical trials.<ref>{{cite news |title=Bharat Biotech to make a billion doses of an intranasal adenovirus vaccine |url=https://indianexpress.com/article/india/bharat-biotech-to-manufacture-a-billion-doses-of-nasal-spray-covid-19-vaccine-6607305/ |work=The Indian Express |date=23 September 2020 |language=en |access-date=23 September 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503051133/https://indianexpress.com/article/india/bharat-biotech-to-manufacture-a-billion-doses-of-nasal-spray-covid-19-vaccine-6607305/ |url-status=live }}</ref><ref>{{cite news |title=Bharat Biotech Partners With US University For Covid Intranasal Vaccine |url=https://www.ndtv.com/india-news/bharat-biotech-partners-with-us-university-for-covid-intranasal-vaccine-2299947 |work=NDTV.com |access-date=23 September 2020 |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503140735/https://www.ndtv.com/india-news/bharat-biotech-partners-with-us-university-for-covid-intranasal-vaccine-2299947 |url-status=live }}</ref>

=== Attempted data theft ===
In March 2021, [[Reuters]] reported that Chinese state-backed cyber-espionage group [[Red Apollo]] targeted Bharat Biotech's intellectual property for [[Data theft|exfiltration]].<ref>{{Cite news|last=Das|first=Krishna N.|date=2021-03-01|title=Chinese hackers target Indian vaccine makers SII, Bharat Biotech, says security firm|language=en|work=[[Reuters]]|url=https://www.reuters.com/article/health-coronavirus-india-china-idUSKCN2AT21O|url-status=live|access-date=2021-03-01|archive-date=3 May 2021|archive-url=https://web.archive.org/web/20210503143320/https://www.reuters.com/article/health-coronavirus-india-china-idUSKCN2AT21O}}</ref>

==See also==
*[[Serum Institute of India]]
*[[Cadila Healthcare]]
*[[Biotechnology in India]]

==References==
{{Reflist}}

==External links==
*[https://www.bharatbiotech.com/ Official site]

{{Authority control}}

[[Category:Pharmaceutical companies of India]]
[[Category:Manufacturing companies based in Hyderabad, India]]
[[Category:Vaccine producers]]
[[Category:Pharmaceutical companies established in 1996]]
[[Category:Biotechnology companies of India]]
[[Category:Biotechnology companies established in 1996]]
[[Category:COVID-19 pandemic in India]]
[[Category:Indian companies established in 1996]]
[[Category:Indian brands]]
[[Category:1996 establishments in Andhra Pradesh]]
[[Category:BSL3 laboratories in India]]

Bharat Biotech - Revision history

>Tayi Arajakate at 00:54, 6 July 2021