Sergzrr at 19:23, 7 February 2026

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{{Short description|Indian molecular biologist (born 1953)}}
{{Use dmy dates|date=August 2018}}
{{Use Indian English|date=August 2018}}
{{Infobox scientist
| name = Ghanshyam Swarup
| image =
| alt =
| caption =
| birth_date = {{Birth date and age|df=yes|1953|11|23}}
| birth_place = [[Uttar Pradesh]], India
| death_date =
| death_place =
| fields = {{ublist | [[Molecular biology]] }}
| workplaces = {{ublist | [[Centre for Cellular and Molecular Biology]] }}
| alma_mater = {{ublist | [[Kanpur University]] | [[Tata Institute of Fundamental Research]] | [[Vanderbilt University School of Medicine]] }}
| doctoral_advisor =
| doctoral_students =
| known_for = Discovery of a nuclear [[protein tyrosine phosphatase]]<br />Studies on [[Glaucoma]]
| awards = 1989 [[Council of Scientific and Industrial Research|CSIR]] Young Scientist Award<br />1996 [[Shanti Swarup Bhatnagar Prize]]
}}

'''Ghanshyam Swarup''' (born 1953) is an Indian [[Molecular Biologist|molecular biologist]], a J. C. Bose National Fellow and the head of the ''Ghanshyam Swarup Research Group'' of the [[Centre for Cellular and Molecular Biology]].<ref name="Ghanshyam Swarup Group">{{cite web | url=http://www.ccmb.res.in/index.php?view=ourteam&mid=0&id=62&grpid=39 | title=Ghanshyam Swarup Group | publisher=Centre for Cellular and Molecular Biology | date=2016 | access-date=10 October 2016}}</ref> He is known for his studies on [[glaucoma]] and the discovery of [[protein tyrosine phosphatase]], a new protein influencing the regulation of cell proliferation.<ref name="Brief Profile of the Awardee">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=87 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> Swarup is an elected fellow of the [[Indian Academy of Sciences]],<ref name="Fellow profile - Swarup">{{cite web | url=http://www.ias.ac.in/describe/fellow/Swarup,_Dr_Ghanshyam | title=Fellow profile - Swarup | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}}</ref> the [[Indian National Science Academy]]<ref name="Indian fellow - Swarup">{{cite web | url=http://insaindia.res.in/detail.php?id=P03-1349 | title=Indian fellow - Swarup | publisher=Indian National Science Academy | date=2016 | access-date=6 October 2016 | archive-date=11 October 2016 | archive-url=https://web.archive.org/web/20161011231134/http://insaindia.res.in/detail.php?id=P03-1349 }}</ref> and the [[National Academy of Sciences, India]].<ref name="NASI fellows">{{cite web|url=http://www.nasi.org.in/fellows.asp?RsFilter=S |title=NASI fellows |publisher=National Academy of Sciences, India |date=2016 |access-date=8 October 2016 |archive-url=https://web.archive.org/web/20160316043224/http://nasi.org.in/fellows.asp?RsFilter=S |archive-date=16 March 2016 }}</ref> The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards, in 1996, for his contributions to biological sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=201 | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref>

== Biography ==

Ghanshyam Swarup, born on 23 November 1953 in the Indian state of [[Uttar Pradesh]], graduated in science from [[Chhatrapati Shahu Ji Maharaj University]] and continued his studies there to secure a master's degree before moving to Mumbai to complete his PhD at [[Tata Institute of Fundamental Research]] (TIFR).<ref name="Indian fellow - Swarup" /> His post-doctoral studies were at [[David L. Garbers]]' laboratory of [[Vanderbilt University School of Medicine]] where he had the opportunity to work alongside [[Stanley Cohen (biochemist)|Stanley Cohen]], the 1986 [[Nobel laureate]]. Returning to India, Swarup joined the [[Centre for Cellular and Molecular Biology]] as a scientist<ref name="CCMB Directory">{{cite web | url=http://www.csir.res.in/External/Heads/aboutcsir/lab%20directory/ccmb.htm | title=CCMB Directory | publisher=Centre for Cellular and Molecular Biology | date=2016 | access-date=10 October 2016 | archive-url=https://web.archive.org/web/20161011225419/http://www.csir.res.in/External/Heads/aboutcsir/lab%20directory/ccmb.htm | archive-date=11 October 2016 }}</ref> and is the head of ''Ghanshyam Swarup Group'' which carries out researches on [[optineurin]] and the functional defects caused in humans by its [[mutation]]s.<ref name="Scientist Details">{{cite web | url=http://www.ccmb.res.in/index.php?view=scientist&mid=0&id=63&grpid=39 | title=Scientist Details | publisher=Centre for Cellular and Molecular Biology | date=2016 | access-date=10 October 2016}}</ref>

== Legacy ==
Swarup, while working with [[Stanley Cohen (biochemist)|Stanley Cohen]] in the US on cellular signaling mechanisms, is reported to have discovered a new nuclear [[protein tyrosine phosphatase]] (PTPase) and his subsequent work demonstrated that the protein plays a part in the regulation of cell proliferation.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | page=32 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 }}</ref> Later, during his early days at CCMB, he elucidated the molecular cloning of a protein tyrosine phosphatase and its bind with [[DNA]] and established the methodology for alternative splicing of a gene to form four different variations of PTPase.<ref name="Indian fellow - Swarup" /> Swarup's studies are known to have assisted in identifying the ''first cargo (PTP-S4/TC48) for the putative cargo receptors in mammalian cells''. He has established a laboratory, ''Ghanshyam Swarup Group'', where his team focuses on researches on protein [[optineurin]] and how disease-associated mutation affect humans.<ref name="Scientist Details" /> Associated with [[L. V. Prasad Eye Institute]], he works on one of the mutated genes of optineurin as a causative factor of [[glaucoma]], an eye disease leading to irrecoverable loss of vision<ref name="Two molecular mechanisms causing glaucoma found">{{cite news | url=http://www.thehindu.com/sci-tech/health/two-molecular-mechanisms-causing-glaucoma-found/article4902049.ece | title=Two molecular mechanisms causing glaucoma found | work=The Hindu | date=10 July 2013 | access-date=10 October 2016| last1=Mallikarjun | first1=Y. }}</ref> and has elaborated on the [[pathogenesis]] in the disease from a molecular perspective.<ref name="Molecular Basis of Pathogenesis in Glaucoma Caused by Mutations in Optineurin">{{cite journal | url=http://www.niscair.res.in/sciencecommunication/RnDNewsLetters/csirnews2k14/csirnews_jan14.pdf | title=Molecular Basis of Pathogenesis in Glaucoma Caused by Mutations in Optineurin | author=Ghanshyam Swarup | journal=CSIR News | date=January 2014 | volume=64 | issue=1}}</ref>

Swarup has published several articles detailing his research findings;{{Refn|group=note|Please see Selected bibliography section}} [[ResearchGate]], an online repository of scientific articles has listed 81 of them.<ref name="Swarup on ResearchGate">{{cite web | url=https://www.researchgate.net/profile/Ghanshyam_Swarup | title=Swarup on ResearchGate | work=Author profile | date=2016 | access-date=10 October 2016}}</ref> He is a member of the editorial board of the ''Journal of Molecular Signaling''<ref name="Editorial board JMS">{{cite web | url=http://www.jmolecularsignaling.com/about/editorialteam/ | title=Editorial board JMS | publisher=Journal of Molecular Signaling | date=2016 | access-date=11 October 2016}}</ref> and is known to be active in the researches done by others.<ref name="Supplemental Data ">{{cite web | url=http://www.cell.com/cms/attachment/597593/4683623/mmc1.pdf | title=Supplemental Data | publisher=Cell.com | date=2016 | access-date=11 October 2016}}</ref> Swarup has mentored several scholars in their doctoral and post-doctoral researches at his research group in CCMB<ref name="Ghanshyam Swarup Group" /> as well as scholars from other institutions.<ref name="Our Scholars">{{cite web | url=http://www.jnu.ac.in/jnunewsarchives/jnunews_may_june08/scholars.htm | title=Our Scholars | publisher=Jawaharlal Nehru University | date=2016 | access-date=11 October 2016 | archive-url=https://web.archive.org/web/20160909144302/http://www.jnu.ac.in/jnunewsarchives/jnunews_may_june08/scholars.htm | archive-date=9 September 2016 }}</ref>

== Awards and honors ==
Swarup, who was elected as a fellow by the [[National Academy of Sciences, India]] in 1988,<ref name="NASI fellows" /> received the Young Scientist Award of the [[Council of Scientific and Industrial Research]] in 1989.<ref name="Indian fellow - Swarup" /> The [[Indian Academy of Sciences]] made him their elected fellow in 1995<ref name="Fellow profile - Swarup" /> and the CSIR honored him again in 1996 with the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards.<ref name="View Bhatnagar Awardees" /> An elected member of the [[Guha Research Conference]], Swarup became an elected fellow of the [[Indian National Science Academy]] in 2003.<ref name="Indian fellow - Swarup" /> In 2011, he was selected for the J. C. Bose National Fellowship of the [[Department of Science and Technology (India)|Department of Science and Technology]]<ref name="CCMB scientists bag J.C. Bose fellowship">{{cite web | url=http://www.thehindubusinessline.com/todays-paper/tp-economy/ccmb-scientists-bag-jc-bose-fellowship/article2326865.ece | title=CCMB scientists bag J.C. Bose fellowship | publisher=The Hindu Business Line | date=20 January 2011 | access-date=11 October 2016}}</ref> on which he pursues his current researches at CCMB.<ref name="Ghanshyam Swarup Group" />

== Selected bibliography ==
* {{cite journal | title=Molecular Basis of Pathogenesis in Glaucoma Caused by Mutations in Optineurin | author=Ghanshyam Swarup | journal=CSIR News | date=January 2014 | volume=64 | issue=1}}
* {{cite journal | title=E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy | author=Madhavi Latha Somaraju Chalasani, Asha Kumari, Vegesna Radha, Ghanshyam Swarup | journal=PLOS ONE | date=April 2014 | volume=9 | issue=4 | doi=10.1371/journal.pone.0095758 | pmid=24752605 | pmc=3994150 | article-number=e95758| bibcode=2014PLoSO...995758C | doi-access=free }}
* {{cite journal | title=Defects in autophagy caused by glaucoma-associated mutations in optineurin | author=Kapil Sirohi, Ghanshyam Swarup | journal=Experimental Eye Research | date=August 2015 | volume=144 | doi=10.1016/j.exer.2015.08.020 | pmid=26302410 | pages=54–63}}
* {{cite journal | title=A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin | author=Kapil Sirohi, Asha Kumari, Vegesna Radha, Ghanshyam Swarup | journal=PLOS ONE | date=October 2015 | volume=10 | issue=9 | doi=10.1371/journal.pone.0138289 | pmid=26376340 | pmc=4574030 | article-number=e0138289| bibcode=2015PLoSO..1038289S | doi-access=free }}

== See also ==
{{Div col}}
* [[Protein tyrosine phosphatase]]
* [[Optineurin]]
* [[Glaucoma]]
* [[Stanley Cohen (biochemist)]]
{{Div col end}}
{{portal|India|Biology}}

== Notes ==
{{reflist|group=note}}

== References ==
{{reflist}}

== External links ==
* {{cite web | url=http://www.tifr.res.in/Alumni_Association/docs/TAA_Members_All.pdf | title=TIFR Alumni Association - Members' list | publisher=TIFR Alumni Association | date=2016 | access-date=10 October 2016}}

{{SSBPST recipients in Biological Science}}

{{authority control}}

{{DEFAULTSORT:Swarup, Ghanshyam}}
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Biological Science]]
[[Category:1953 births]]
[[Category:Indian molecular biologists]]
[[Category:Indian geneticists]]
[[Category:Living people]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:Fellows of the National Academy of Sciences, India]]
[[Category:Scientists from Uttar Pradesh]]
[[Category:Chhatrapati Shahu Ji Maharaj University alumni]]
[[Category:Tata Institute of Fundamental Research alumni]]
[[Category:Vanderbilt University School of Medicine alumni]]
[[Category:20th-century Indian biologists]]

Ghanshyam Swarup - Revision history

Sergzrr at 19:23, 7 February 2026