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&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;{{Short description|Indian scientific research institute}}&lt;br /&gt;
{{COI|date=March 2025}}&lt;br /&gt;
{{Use dmy dates|date=September 2018}}&lt;br /&gt;
{{Use Indian English|date=September 2018}}&lt;br /&gt;
{{Infobox organization&lt;br /&gt;
| name                = CSIR Institute of Genomics and Integrative Biology&lt;br /&gt;
| image               = File:Institute of Genomics and Integrative Biology.svg&lt;br /&gt;
| image_size          = &lt;br /&gt;
| abbreviation        = CSIR-IGIB&lt;br /&gt;
| established         = 1977&lt;br /&gt;
| leader_title        = Director&lt;br /&gt;
| leader_name         = [[Souvik Maiti]]&lt;br /&gt;
| num_staff           = &lt;br /&gt;
| budget              = &lt;br /&gt;
| endowment           = &lt;br /&gt;
| predecessor         = [[Center for Biochemical Technology]]&lt;br /&gt;
| location            = Sukhdev Vihar, Mathura Road,&amp;lt;br /&amp;gt;[[Delhi]]-110 025.&lt;br /&gt;
| website             = {{URL|http://www.igib.res.in}}&lt;br /&gt;
| formation           = &lt;br /&gt;
| extinction          = &lt;br /&gt;
| type                = [[Government organization]]&lt;br /&gt;
| status              = &lt;br /&gt;
| purpose             = To translate concepts developed in basic biological research to commercially viable technologies for health care&lt;br /&gt;
| headquarters        = &lt;br /&gt;
| region_served       = &lt;br /&gt;
| num_members         = &lt;br /&gt;
| language            = &lt;br /&gt;
| main_organ          = &lt;br /&gt;
| parent_organization = [[Council of Scientific and Industrial Research]]&lt;br /&gt;
}}&lt;br /&gt;
[[File:CSIR-IGIB, South Campus.jpg|thumb|right|CSIR-IGIB South Campus]]&lt;br /&gt;
&amp;#039;&amp;#039;&amp;#039;CSIR Institute of Genomics and Integrative Biology&amp;#039;&amp;#039;&amp;#039; (&amp;#039;&amp;#039;&amp;#039;CSIR-IGIB&amp;#039;&amp;#039;&amp;#039;) is a scientific [[research institute]] devoted primarily to biological research. It is a part of [[Council of Scientific and Industrial Research]] (CSIR), India.&amp;lt;ref&amp;gt;[http://csir.res.in Council of Scientific and Industrial Research India Website] {{webarchive|url=https://web.archive.org/web/20150927141436/http://csir.res.in/ |date=2015-09-27 }}.&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The institute was founded in 1977 as the [[Center for Biochemical Technology]] with a primary focus on biochemical research, but has since shifted its research focus to integrative biology.&lt;br /&gt;
&lt;br /&gt;
==Location==&lt;br /&gt;
The Institute has two campuses in Delhi. The North Campus is the older of the two campuses and is in the campus of [[Delhi University]], on Mall Road opposite to Jubilee Hall. &lt;br /&gt;
The new campus is in [[South Delhi]], on Mathura Road at Sukhdev Vihar.&lt;br /&gt;
&lt;br /&gt;
== History ==&lt;br /&gt;
&lt;br /&gt;
IGIB was established in 1977 as the [[Center for Biochemical Technology]] (CBT). The Functional Genomics Unit was established in 1998 with the focus shifting from chemical to genomics research. The institute was renamed &amp;quot;Institute of Genomics and Integrative Biology&amp;quot; in 2002. [[Samir K. Brahmachari]] served as the founder director, followed by [[Rajesh S. Gokhale]] and [[Anurag Agrawal (medical scientist)|Anurag Agrawal]].&amp;lt;ref&amp;gt;[[Anurag Agrawal (medical scientist)]]&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== Achievements ==&lt;br /&gt;
In 2009, a team at the institute sequenced the [[genome]] of the wild-type [[zebrafish]], with about 1.7 billion base pairs. This made the fish, which is native to the [[Himalayas|Himalayan]] region, the first [[vertebrate]] to have its whole genome sequenced in India, as previously Indian scientists had only sequenced bacteria and plant genomes.&amp;lt;ref&amp;gt;[http://genome.igib.res.in Zebrafish Genome Webpage] {{Webarchive|url=https://web.archive.org/web/20180719084933/http://genome.igib.res.in/ |date=19 July 2018 }} &amp;#039;Institute of Genomics and Integrative Biology&amp;#039; (IGIB)&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://www.indianexpress.com/news/Decoding-the-Genome-Mystery/485122 Decoding the Genome Mystery] [[Indian Express]], 5 July 2009.&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
In December 2009, scientists at IGIB performed the first re-sequencing of a human genome in India.&amp;lt;ref&amp;gt;[http://www.indianexpress.com/videoie.php?videoId=201 Indian Scientists decode human genome] &amp;#039;&amp;#039;[[Indian Express]]&amp;#039;&amp;#039;, 10 December 2009 {{dead link|date=September 2018}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;* {{cite journal |display-authors=6 |vauthors=Patowary A, Purkanti R, Singh M, Chauhan RK, Bhartiya D, Dwivedi OP, Chauhan G, Bharadwaj D, Sivasubbu S, Scaria V |date=July 2012 |title=Systematic analysis and functional annotation of variations in the genome of an Indian individual |journal=Human Mutation |volume=33 |issue=7 |pages=1133–40 |doi=10.1002/humu.22091 |pmid=22461382 |s2cid=11466942 |doi-access=free}} [http://onlinelibrary.wiley.com/doi/10.1002/humu.22091/pdf]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://vinodscaria.rnabiology.org/indian-genome Compilation of news articles and Press releases on Indian Genome], 10 December 2009&amp;lt;/ref&amp;gt; The Institute also collaborated on decoding the first Sri Lankan&amp;lt;ref&amp;gt;{{Cite web |url=http://genome.igib.res.in/SriLankan/ |title=Sri Lankan genome  |access-date=17 January 2013 |archive-url=https://archive.today/20130218040054/http://genome.igib.res.in/SriLankan/ |archive-date=18 February 2013 }}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite journal |display-authors=etal |vauthors=Dissanayake VH, Samarakoon PS, Scaria V, Patowary A, Sivasubbu S, Gokhale RS |year=2012 |title=The Sri Lankan Personal Genome Project: an overview. |journal=Sri Lanka Journal of Biomedical Informatics |volume=1 |issue=2 |pages=4–8}} [http://www.sljol.info/index.php/SLJBMI/article/download/3711/3073] {{Webarchive|url=https://web.archive.org/web/20130405005110/http://www.sljol.info/index.php/SLJBMI/article/download/3711/3073|date=5 April 2013}}&amp;lt;/ref&amp;gt; genome and Malaysian genome.&amp;lt;ref&amp;gt;{{Cite web | url=http://promiseuitm.org/component/content/article/34-slideshow/50-the-first-malay-genome.html | title=Wedding Day Ancilleries }}{{Dead link|date=May 2019 |bot=InternetArchiveBot |fix-attempted=yes }}&amp;lt;/ref&amp;gt; The Institute is also a member of the Open Personal Genomics Consortium.&amp;lt;ref&amp;gt;{{Cite web |url=http://openpgx.org/ |title=OpenPGx Consortium |access-date=7 November 2018 |archive-url=https://web.archive.org/web/20171218064848/http://www.openpgx.org/ |archive-date=18 December 2017 }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===COVID-19 pandemic===&lt;br /&gt;
&lt;br /&gt;
The institute plays a leading role in the understanding of new variants of SARS-CoV-2 in India&amp;lt;ref&amp;gt;{{Cite news|last=Dandekar|first=Vikas|title=Genome meets GitHub: Using tech tools, India&amp;#039;s virus hunters track a shape-shifting killer|work=The Economic Times|url=https://economictimes.indiatimes.com/prime/pharma-and-healthcare/genome-meets-github-using-tech-tools-indias-virus-hunters-track-a-shape-shifting-killer/primearticleshow/85014368.cms|access-date=2021-08-14}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite web|date=2021-08-03|title=How one of India&amp;#039;s premier research institutes is tracking new SARS-COV2 variants|url=https://indianexpress.com/article/cities/pune/how-one-of-indias-premier-research-institutes-is-tracking-new-sars-cov2-variants-7436040/|access-date=2021-08-14|website=The Indian Express|language=en}}&amp;lt;/ref&amp;gt; and across the world.&amp;lt;ref&amp;gt;{{Cite web|title=Meet the people who warn the world about new covid variants|url=https://www.technologyreview.com/2021/07/26/1030017/covid-variants-pangolin-pango-volunteers/|access-date=2021-08-14|website=MIT Technology Review|language=en}}&amp;lt;/ref&amp;gt; The institute also maintains a number of informatics resources which are key to identification and characterization of emerging variants of SARS-CoV-2.&amp;lt;ref name=&amp;quot;:0&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;:1&amp;quot; /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Researchers at the institute reported the first high-throughput&amp;lt;ref&amp;gt;{{Cite web|date=2020-09-24|title=Plans afoot to set up megalabs in four states to strengthen surveillance|url=https://www.hindustantimes.com/india-news/plans-afoot-to-set-up-megalabs-in-four-states-to-strengthen-surveillance/story-jAY7kVgamJ65nhCO0ekzBI.html|access-date=2020-10-30|website=Hindustan Times|language=en}}&amp;lt;/ref&amp;gt; next-generation sequencing based approach for detection and genetic epidemiology of SARS-CoV-2.&amp;lt;ref&amp;gt;{{Cite journal|last1=Bhoyar|first1=Rahul C.|last2=Jain|first2=Abhinav|last3=Sehgal|first3=Paras|last4=Divakar|first4=Mohit Kumar|last5=Sharma|first5=Disha|last6=Imran|first6=Mohamed|last7=Jolly|first7=Bani|last8=Ranjan|first8=Gyan|last9=Rophina|first9=Mercy|last10=Sharma|first10=Sumit|last11=Siwach|first11=Sanjay|title=High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next-generation sequencing |journal=PLOS ONE |date=2021 |volume=16 |issue=2 |article-number=e0247115 |doi=10.1371/journal.pone.0247115 |doi-access=free |bibcode=2021PLoSO..1647115B |language=en|biorxiv=10.1101/2020.08.10.242677|pmc=7888613}}&amp;lt;/ref&amp;gt; This approach has been extensively used to understand the genetic epidemiology of SARS-CoV-2 in the state of [[Kerala]],&amp;lt;ref&amp;gt;{{Cite news|last=Maya|first=C.|date=2020-09-12|title=Inter-State travel brought coronavirus strains to Kerala: study|language=en-IN|work=The Hindu|url=https://www.thehindu.com/news/national/kerala/inter-state-travel-brought-virus-strains-to-kerala-study/article32585202.ece|access-date=2020-10-30|issn=0971-751X}}&amp;lt;/ref&amp;gt; which has significantly influenced policy and preparedness&amp;lt;ref&amp;gt;{{Cite news|last=Bhagat|first=Shalini Venugopal|date=2021-05-23|title=As India Stumbles, One State Charts Its Own Covid Course|language=en-US|work=The New York Times|url=https://www.nytimes.com/2021/05/23/world/asia/coronavirus-kerala.html|access-date=2021-05-28|issn=0362-4331}}&amp;lt;/ref&amp;gt; in the state to curb the spread of the epidemic as well as implementation of evidence based policies.&amp;lt;ref&amp;gt;{{Cite web|date=2021-05-01|title=Pinarayi pushes for double masking; more curbs planned in Kerala|url=https://indianexpress.com/article/cities/thiruvananthapuram/pinarayi-pushes-for-double-masking-more-curbs-planned-in-kerala-7297406/|access-date=2021-05-28|website=The Indian Express|language=en}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The institute has been instrumental in creating the concept of MegaLabs for COVID-19 testing and genomic surveillance&amp;lt;ref&amp;gt;{{Cite news|last=Koshy|first=Jacob|date=2020-08-12|title=Coronavirus {{!}} CSIR moots &amp;#039;mega labs&amp;#039; to boost COVID-19 testing|language=en-IN|work=The Hindu|url=https://www.thehindu.com/sci-tech/health/csir-moots-mega-labs-to-boost-covid-19-testing/article32337492.ece|access-date=2021-08-14|issn=0971-751X}}&amp;lt;/ref&amp;gt; which also provided the genetic epidemiology of states including Kerala,&amp;lt;ref&amp;gt;{{Cite journal|last1=Radhakrishnan|first1=Chandni|last2=Divakar|first2=Mohit Kumar|last3=Jain|first3=Abhinav|last4=Viswanathan|first4=Prasanth|last5=Bhoyar|first5=Rahul C.|last6=Jolly|first6=Bani|last7=Imran|first7=Mohamed|last8=Sharma|first8=Disha|last9=Rophina|first9=Mercy|last10=Ranjan|first10=Gyan|last11=Sehgal|first11=Paras|date=2021|title=Initial Insights Into the Genetic Epidemiology of SARS-CoV-2 Isolates From Kerala Suggest Local Spread From Limited Introductions|journal=Frontiers in Genetics|volume=12|article-number=630542|language=English|doi=10.3389/fgene.2021.630542|pmid=33815467|issn=1664-8021|pmc=8010186|doi-access=free}}&amp;lt;/ref&amp;gt; Andhra Pradesh&amp;lt;ref&amp;gt;{{Cite journal|last1=Rani|first1=Pallavali Roja|last2=Imran|first2=Mohamed|last3=Lakshmi|first3=J. Vijaya|last4=Jolly|first4=Bani|last5=Afsar|first5=S.|last6=Jain|first6=Abhinav|last7=Divakar|first7=Mohit Kumar|last8=Suresh|first8=Panyam|last9=Sharma|first9=Disha|last10=Rajesh|first10=Nambi|last11=Bhoyar|first11=Rahul C.|date=3 August 2021|title=Insights from genomes and genetic epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh|journal=Epidemiology &amp;amp; Infection|language=en|volume=149|article-number=e181|doi=10.1017/S0950268821001424|issn=0950-2688|pmc=8367868}}&amp;lt;/ref&amp;gt; and Maharashtra.&amp;lt;ref&amp;gt;{{Cite web|date=2021-05-03|title=Maharashtra approaches IGIB to perform genome sequencing of coronavirus samples|url=https://indianexpress.com/article/cities/pune/pune-approaches-igib-to-perform-genome-sequencing-of-coronavirus-samples-covid-mutant-variant-7299637/|access-date=2021-08-14|website=The Indian Express|language=en}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Researchers at the institute also reported the first cases of COVID-19 reinfection in the country&amp;lt;ref&amp;gt;{{Cite journal|last1=Gupta|first1=Vivek|last2=Bhoyar|first2=Rahul C.|last3=Jain|first3=Abhinav|last4=Srivastava|first4=Saurabh|last5=Upadhayay|first5=Rashmi|last6=Imran|first6=Mohamed|last7=Jolly|first7=Bani|last8=Divakar|first8=Mohit Kumar|last9=Sharma|first9=Disha|last10=Sehgal|first10=Paras|last11=Ranjan|first11=Gyan|title=Asymptomatic Reinfection in 2 Healthcare Workers From India With Genetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2|url= |journal=Clinical Infectious Diseases|year=2020|volume=73 |issue=9 |pages=e2823–e2825 |language=en|doi=10.1093/cid/ciaa1451|pmc=7543380|pmid=32964927}}&amp;lt;/ref&amp;gt; apart from identifying a novel clade of SARS-CoV-2 in India named I/A3i.&amp;lt;ref&amp;gt;{{Cite journal|last1=Banu|first1=Sofia|last2=Jolly|first2=Bani|last3=Mukherjee|first3=Payel|last4=Singh|first4=Priya|last5=Khan|first5=Shagufta|last6=Zaveri|first6=Lamuk|last7=Shambhavi|first7=Sakshi|last8=Gaur|first8=Namami|last9=Reddy|first9=Shashikala|last10=Kaveri|first10=K.|last11=Srinivasan|first11=Sivasubramanian|title=A distinct phylogenetic cluster of Indian SARS-CoV-2 isolates|url= |journal=Open Forum Infectious Diseases|year=2020|volume=7|issue=11|article-number=ofaa434|language=en|doi=10.1093/ofid/ofaa434|pmid=33200080|pmc=7543508}}&amp;lt;/ref&amp;gt; Researchers at the institute also discovered an emerging lineage with N440K mutation in spike protein associated with immune escape.&amp;lt;ref&amp;gt;{{Cite web|date=2020-12-27|title=Indian Covid-19 mutation &amp;#039;N440k&amp;#039; found in one-third of Andhra Pradesh&amp;#039;s coronavirus genomes|url=https://www.deccanherald.com/science-and-environment/indian-covid-19-mutation-n440k-found-in-one-third-of-andhra-pradeshs-coronavirus-genomes-932259.html|access-date=2020-12-28|website=Deccan Herald|language=en}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite bioRxiv|last1=Jolly|first1=Bani|last2=Rophina|first2=Mercy|last3=Shamnath|first3=Afra|last4=Imran|first4=Mohammed|last5=Bhoyar|first5=Rahul C.|last6=Divakar|first6=Mohit Kumar|last7=Rani|first7=Pallavi Roja|last8=Ranjan|first8=Gyan|last9=Sehgal|first9=Paras|last10=Chandrasekhar|first10=Pulala|last11=Afsar|first11=S.|date=2020-12-26|title=Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes|language=en|biorxiv=10.1101/2020.12.24.424332}}&amp;lt;/ref&amp;gt; A comprehensive suite for computational resources to understand the genomes and genetic epidemiology of SARS-CoV-2 has been maintained.&amp;lt;ref name=&amp;quot;:1&amp;quot;&amp;gt;{{Cite web|title=Genetic epidemiology of novel and emerging pathogens in India|url=http://clingen.igib.res.in/genepi|access-date=2020-10-30|website=clingen.igib.res.in|language=en}}&amp;lt;/ref&amp;gt; One of the first genetically characterized cases of COVID-19 vaccine breakthrough infections was reported by the institute.&amp;lt;ref&amp;gt;{{Cite journal|last1=J|first1=Beena Philomina|last2=Jolly|first2=Bani|last3=John|first3=Neethu|last4=Bhoyar|first4=Rahul C.|last5=Majeed|first5=Nisha|last6=Senthivel|first6=Vigneshwar|last7=P|first7=Fairoz C.|last8=Rophina|first8=Mercy|last9=Vasudevan|first9=Bindhu|last10=Imran|first10=Mohamed|last11=Viswanathan|first11=Prasanth|date=2021-05-24|title=Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India|url=https://www.journalofinfection.com/article/S0163-4453(21)00260-7/abstract|journal=Journal of Infection|volume=83|issue=2|pages=237–279|language=English|doi=10.1016/j.jinf.2021.05.018|issn=0163-4453|pmid=34044037|pmc=8143909}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Researchers at the institute have been instrumental in the development of COVIDSure&amp;lt;ref&amp;gt;{{Cite web|date=14 August 2021|title=CSIR Technologies for COVID-19 Mitigation|url=https://www.csir.res.in/sites/default/files/Final%20Covid-19%20Compendium-Jan2021.pdf|website=Council of Scientific and Industrial Research}}&amp;lt;/ref&amp;gt; an [[Reverse transcription polymerase chain reaction]] based kit for diagnosis of COVID-19 and now widely used in India and marketed by [[Trivitron]] Healthcare.&amp;lt;ref&amp;gt;{{Cite web|title=COVIDsure Multiplex Realtime RT-PCR Kit {{!}} qualitative RT-PCR assay for COVID-19|url=https://www.trivitron.com/products/covid-19/covid-19-testing-kits/covidsure-multiplex-realtime-rt-pcr-kit|access-date=2021-08-14|website=www.trivitron.com}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Researchers at CSIR-IGIB also developed the test called FELUDA based on [[CRISPR gene editing]] which is highly efficient and fast to combat the testing capacity of the country and has been approved by [[Drugs Controller General of India]]. The test has been licensed to [[Tata Group]] for commercial production.&amp;lt;ref&amp;gt;{{Cite web|last=Rajalakshmi|first=Niranjana|date=2020-10-28|title=Explained: How Does India&amp;#039;s Feluda COVID-19 Test Work?|url=https://science.thewire.in/the-sciences/explained-feluda-covid-19-test-india-crispr-technology/|access-date=2020-10-30|website=The Wire Science|language=en-GB}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The institute has also been playing a leading role in the national COVID-19 genomics consortium&amp;lt;ref&amp;gt;{{cite web |title=INSACOG {{!}} Department of Biotechnology |url=https://dbtindia.gov.in/insacog |website=Government of India Ministry of Science &amp;amp; Technology |access-date=28 September 2021}}&amp;lt;/ref&amp;gt; and maintains the informatics resources and dashboards.&amp;lt;ref name=&amp;quot;:0&amp;quot;&amp;gt;{{Cite web|title=COVID-19 Genomic Surveillance|url=http://clingen.igib.res.in/covid19genomes/|access-date=2021-08-14|website=clingen.igib.res.in}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== Genomics of rare genetic diseases ==&lt;br /&gt;
The institute has initiated a unique programme to use cutting-edge genomic technologies to understand Rare [[genetic diseases]] in India and pioneering the application of genomics for [[Precision Medicine]] in clinics. One of the programmes which has been initiated on this front is Genomics for Understanding Rare Disease, India Alliance Network (GUaRDIAN).&amp;lt;ref&amp;gt;{{Cite web |url=http://guardian.meragenome.com/ |title=Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN) |access-date=17 September 2015 |archive-date=16 May 2021 |archive-url=https://web.archive.org/web/20210516025449/http://guardian.meragenome.com/ }}&amp;lt;/ref&amp;gt; GUaRDIAN is a large-scale collaborative network of clinicians from around India trying to use genomics in clinical practice, with the focused aim to understand genetic structure of rare genetic diseases in India.&amp;lt;ref&amp;gt;{{cite journal | vauthors = Sivasubbu S, Scaria V | collaboration = GUaRDIAN Consortium | title = Genomics of rare genetic diseases-experiences from India | journal = Human Genomics | volume = 14 | issue = 1 | article-number = 52 | date = September 2019 | pmid = 31554517 | pmc = 6760067 | doi = 10.1186/s40246-019-0215-5 | doi-access = free }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The consortium aims at using cutting-edge genomics technology to enable identification of genetic variations in diseases and enable clinicians arrive at precise diagnosis for rare genetic disease. Apart from working closely with clinicians, the consortium aims to foster education, awareness and the widespread adoption of genomic technology in clinical settings, in addition to creating and disseminating the highest standards of genomic data generation and interpretation in India.&amp;lt;ref&amp;gt;{{cite book | first1 = Vinod | last1 = Scaria | first2 = Sridhar | last2 = Sivasubbu | name-list-style = vanc | publisher = The Readers Paradise | edition = First | date = 2015 | url = http://guardian.meragenome.com/exome-sequence-analysis-and-interpretation | title = Exome Sequence Analysis and Interpretation - Handbook for Clinicians | isbn = 978-93-82110-58-3 | archive-date = 12 April 2016 | access-date = 17 September 2015 | archive-url = https://web.archive.org/web/20160412000042/http://guardian.meragenome.com/exome-sequence-analysis-and-interpretation }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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In the few years, it has been able to work closely with clinicians in the network to be able to offer proof of principles for the application of Genomics for Precision Medicine.&amp;lt;ref&amp;gt;{{cite journal | vauthors = Gupta A, Sharma YK, Vellarikkal SK, Jayarajan R, Dixit V, Verma A, Sivasubbu S, Scaria V | display-authors = 6 | title = Whole-exome sequencing solves diagnostic dilemma in a rare case of sporadic acrokeratosis verruciformis | journal = Journal of the European Academy of Dermatology and Venereology | volume = 30 | issue = 4 | pages = 695–7 | date = April 2016 | pmid = 25622760 | doi = 10.1111/jdv.12983 | s2cid = 35181817 | doi-access = free }}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{cite journal | vauthors = Gupta A, Sharma Y, Deo K, Vellarikkal S, Jayarajan R, Dixit V, Verma A, Scaria V, Sivasubbu S | display-authors = 6 | title = Case Report: Whole exome sequencing helps in accurate molecular diagnosis in siblings with a rare co-occurrence of paternally inherited 22q12 duplication and autosomal recessive non-syndromic ichthyosis | journal = F1000Research | volume = 4 | page = 446 | year = 2015 | pmid = 26594337 | pmc = 4648218 | doi = 10.12688/f1000research.6779.1 | doi-access = free }}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{cite journal | vauthors = Vellarikkal SK, Patowary A, Singh M, Kumari R, Faruq M, Master DC, Sivasubbu S, Scaria V | display-authors = 6 | title = Exome sequencing reveals a novel mutation, p.L325H, in the KRT5 gene associated with autosomal dominant Epidermolysis Bullosa Simplex Koebner type in a large family from western India | journal = Human Genome Variation | volume = 1 | issue = 1 | article-number = 14007 | year = 2014 | pmid = 27081501 | pmc = 4785511 | doi = 10.1038/hgv.2014.7 }}&amp;lt;/ref&amp;gt; A comprehensive programme for patient referral is also functional.&amp;lt;ref&amp;gt;{{Cite web |url=http://guardian.meragenome.com/referral |title=Patient Referral Page Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN) |access-date=17 September 2015 |archive-date=4 March 2016 |archive-url=https://web.archive.org/web/20160304134654/http://guardian.meragenome.com/referral }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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== IndiGen Programme for Public Health ==&lt;br /&gt;
The IndiGen programme on Public Health Genomics&amp;lt;ref&amp;gt;{{Cite web|url=https://sites.google.com/igib.in/indigen|title=Genomics for Public Health|website=sites.google.com|language=en-US|access-date=2019-09-03}}&amp;lt;/ref&amp;gt; aims to undertake whole genome sequencing  of 1000 Indian individuals representing diverse ethnic groups from India. The data generated as part of IndiGen would provide the baseline for allele frequencies of genetic variants for genetic epidemiology and aid policy decisions. The frequencies of clinically relevant genetic variants would form the template for enabling diagnostic approaches for prevalent genetic diseases and also for optimising therapies through pharmacogenomics. A comprehensive resource providing searchable access to the data is also made available.&amp;lt;ref&amp;gt;{{Cite journal|last1=Jain|first1=Abhinav|last2=Bhoyar|first2=Rahul C.|last3=Pandhare|first3=Kavita|last4=Mishra|first4=Anushree|last5=Sharma|first5=Disha|last6=Imran|first6=Mohamed|last7=Senthivel|first7=Vigneshwar|last8=Divakar|first8=Mohit Kumar|last9=Rophina|first9=Mercy|last10=Jolly|first10=Bani|last11=Batra|first11=Arushi|title=IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes|journal=Nucleic Acids Research|year=2020|volume=49|issue=D1|pages=D1225–D1232|language=en|doi=10.1093/nar/gkaa923|pmid=33095885|pmc=7778947|doi-access=free}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Extension Centers (Branches)==&lt;br /&gt;
The main IGIB campus is located at Mall Road, New Delhi near Delhi University North Campus. IGIB&amp;#039;s alliance with the Biotech/Pharmaceuticals has led to its growth and setting up of two extension centers - one at South Delhi (IGIB Annex at TCGA, Okhla) and the other at Western Delhi at Naraina.&lt;br /&gt;
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==International Meetings==&lt;br /&gt;
IGIB was a co-host of the 13th meeting of the [[Human Genome Organization]] (HUGO) in 2008, held at [[Hyderabad International Convention Centre]].&amp;lt;ref&amp;gt;[http://hgm2008.hugo-international.org HGM-2008 website] {{Webarchive|url=https://web.archive.org/web/20161002181021/http://hgm2008.hugo-international.org/ |date=2 October 2016 }}.&amp;lt;/ref&amp;gt;&lt;br /&gt;
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== See also ==&lt;br /&gt;
*[[National Institute of Biomedical Genomics]]&lt;br /&gt;
*[http://www.nipgr.res.in/home/home.php National Institute of Plant Genome Research] {{Webarchive|url=https://web.archive.org/web/20110216032613/http://www.nipgr.res.in/home/home.php |date=16 February 2011 }}&lt;br /&gt;
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== References ==&lt;br /&gt;
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== External links ==&lt;br /&gt;
* [http://igib.res.in IGIB Official Website]&lt;br /&gt;
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{{DEFAULTSORT:Institute Of Genomics And Integrative Biology}}&lt;br /&gt;
[[Category:Scientific organisations based in India]]&lt;br /&gt;
[[Category:Genomics]]&lt;br /&gt;
[[Category:Bioinformatics organizations]]&lt;br /&gt;
[[Category:Council of Scientific and Industrial Research]]&lt;br /&gt;
[[Category:Biological research institutes]]&lt;br /&gt;
[[Category:Research institutes in Delhi]]&lt;br /&gt;
[[Category:Research institutes established in 1977]]&lt;br /&gt;
[[Category:1977 establishments in Delhi]]&lt;/div&gt;</summary>
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