WikiDwarfBOT at 09:49, 22 July 2023

2023-07-22T09:49:40Z

New page

{{Infobox scientist
| name = Irvine Page
| image = Dr. Irvine Page and Lab Tech 1960s A3112.jpg
| image_size =
| caption = Page (right) and lab tech in the 1960s
| birth_name = Irvine Heinly Page
| birth_date = {{birth date|1901|1|7}}
| birth_place = [[Indianapolis]], [[Indiana]], US
| death_date = {{Death date and age|1991|6|10|1901|1|7}}
| death_place = [[Hyannis Port, Massachusetts|Hyannis Port]], [[Massachusetts]], US
| residence =
| citizenship =
| nationality =
| ethnicity =
| field =
| work_institutions =
| alma_mater =
| doctoral_advisor =
| doctoral_students =
| known_for =
| author_abbrev_bot =
| author_abbrev_zoo =
| influences =
| influenced =
| prizes =
| religion =
| footnotes =
| signature =
}}
'''Irvine Heinly Page''' (January 7, 1901 – June 10, 1991) was an American [[physiology|physiologist]] who played an important part in the field of [[hypertension]] for almost 60 years while working at the [[Cleveland Clinic]] as the first Chair of Research.<ref>{{cite journal | last1 = Dustan | author-link = Harriet P. Dustan | first1 = HP | title = Irvine Page lecture. Legacies of Irvine H. Page. | journal = Journal of Hypertension Supplement | volume = 8 | issue = 7 | pages = S29–34 | year = 1990 | pmid = 2095393 }}</ref><ref>Dustan HP ''[http://books.nap.edu/readingroom/books/biomems/ipage.pdf Irvine Heinly Page.]'' The National Academies Press Biographical Memoirs.</ref><ref name="dustan1991">Frohlich ED, [[Harriet P. Dustan|Dustan HP]], Bumpus FM ''[http://hyper.ahajournals.org/cgi/reprint/18/4/443.pdf Irvine H. Page: 1901-1991. The Celebration of a Leader]'' Hypertension 1991;18:443–445.</ref>

==Early life and education==
Irvine Page was born on January 7, 1901, in Indianapolis, Indiana. He attended college at [[Cornell University]], with an undergraduate degree in chemistry (1921) and an M.D. degree in 1926.<ref>https://news.weill.cornell.edu/sites/default/files/publications/wcm_vol15_no3.pdf {{Bare URL PDF|date=March 2022}}</ref><ref>http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/page-irvine.pdf {{Bare URL PDF|date=March 2022}}</ref> Page completed his internship at [[Presbyterian Hospital (New York City)|Presbyterian]] and [[Bellevue Hospital]]s in New York City.<ref name="gifford1987">{{cite journal |last1=Gifford |first1=R. |title=Profiles in cardiology: Irvine h. page |journal=Clinical Cardiology |date=January 1987 |volume=10 |issue=1 |pages=68–69 |doi=10.1002/clc.4960100117|pmid=3545576 |doi-access=free }}</ref>

==Career==
After completing his internship, Page then performed research in [[physical chemistry]] at Woods Hole and then New York. In 1928 he joined the [[Kaiser Wilhelm Society|Kaiser Wilhelm Institute]] in [[Munich]], [[Germany]] where he started a new department of [[neurochemistry]]. With the coming rise to power of [[Hitler]], Page left Munich in 1931 to work with [[Donald Van Slyke]] at [[Rockefeller University|The Rockefeller Institute for Medical Research]] in New York City. He worked at the Rockefeller Institute through 1937. Page then moved back to Indianapolis as Director of the Laboratory for Clinical Research at [[Eli Lilly and Company|Eli Lilly]] at [[Sidney & Lois Eskenazi Hospital|City Hospital]]. In 1945, Page then organized a new research division at the [[Cleveland Clinic]].<ref name="gifford1987" />

His first contributions were published in the early 1930s and his most recent, "Hypertension Research: A Memoir: 1920–1960", in 1988. He is perhaps best known for the co-discovery of [[serotonin]] in 1948,<ref>{{cite journal | last1 = Rapport | first1 = MM | last2 = Green | first2 = AA | last3 = Page | first3 = IH | year = 1948 | title = Serum vasoconstrictor (serotonin). IV. Isolation and characterization | journal = J Biol Chem | volume = 176 | issue = 3| pages = 1243–1251 | doi = 10.1016/S0021-9258(18)57137-4 | pmid = 18100415 | doi-access = free }}</ref> although his pre-eminence is a matter of record in four other areas: the [[renin–angiotensin system]], the mosaic theory of hypertension,<ref>{{cite journal | last1 = Page | first1 = IH | title = The mosaic theory of arterial hypertension--its interpretation. | journal = Perspectives in Biology and Medicine | volume = 10 | issue = 3 | pages = 325–33 | year = 1967 | pmid = 6034593 | doi=10.1353/pbm.1967.0031| s2cid = 29576640 }}</ref> treatment of hypertension and public and professional [[advocacy]] of the recognition of this condition and its effects in daily life. In earlier work he published on the [[neurochemistry]] of the [[brain]].

Page received many honors for his work. He was on the cover of Time magazine in 1955.<ref>[https://web.archive.org/web/20061026072848/http://www.time.com/time/covers/0%2C16641%2C19551031%2C00.html issue]</ref> He was president of the [[American Heart Association]] (1956–57); he received ten [[honorary degrees]] and a number of prestigious awards—the Ida B. Gould Memorial Award of the [[American Association for the Advancement of Science]] (1957); Albert [[Lasker Award]] (1958); [[Gairdner Foundation International Award]] (1963); Distinguished Award of the [[American Medical Association]] (1964); [[Oscar B. Hunter Award]] (1966); Golden Plate Award of the [[Academy of Achievement|American Academy of Achievement]] (1966);<ref>{{cite web|title= Golden Plate Awardees of the American Academy of Achievement |website=www.achievement.org|publisher=[[American Academy of Achievement]]|url=https://achievement.org/our-history/golden-plate-awards/#science-exploration}}</ref> [[Passano Foundation]] Award (1967); and the Stouffer Prize (now the [[Novartis]] Award) for Hypertension Research in 1970. He was elected to the [[United States National Academy of Sciences|National Academy of Sciences]] in 1971 and published his memoirs in 1988.

The American Heart Association [http://www.heart.org/presenter.jhtml?identifier=3041097 Irvine H. Page Young Investigator Research Award] {{Webarchive|url=https://web.archive.org/web/20070927024409/http://www.heart.org/presenter.jhtml?identifier=3041097 |date=2007-09-27 }} and the [http://www.americanheart.org/presenter.jhtml?identifier=491 Irvine Page – Alva Bradley Lifetime Achievement Award] are named in his honor.

==Later life==
A collection of his papers is held at the National Library of Medicine in Bethesda, Maryland.<ref>{{cite web|url=http://oculus.nlm.nih.gov/page386|title=Irvine H. Page, M.D. Papers 1917–1989|publisher=National Library of Medicine}}</ref>

===Personal life===
He was married to Beatrice Allen, a dancer, poet, and author of the book, The Bracelet. His sister was [[Ruth Page (ballerina)|Ruth Page]], a noted American ballet dancer. Page was also a gifted musician, a trait he passed on to his two sons, Christopher Page and Nicholas Page. Page lived in Cleveland, OH with his wife and children, summering in Hyannis Port on Cape Cod. His family home on the Cape is now owned and occupied by his granddaughter and great-grandchildren.

===Death===
Having retired to Hyannis Port, Massachusetts, Page died suddenly on June 10, 1991, at the age of 90. He had been previously injured in an auto accident in March 1990 and suffered from poor health due to a prior stroke and a prior heart attack.<ref name="dustan1991" />

==Selected publications==
*{{cite book|last=Page|first=Irvine|title=Hypertension Mechanisms|year=1987|publisher=Grune & Stratton|location=Orlando, Fla.|isbn=978-0-8089-1768-7}}
*{{cite book|last=Page|first=Irvine|title=Hypertension Research: A Memoir : 1920-1960|year=1988|publisher=Pergamon|location=New York|isbn=978-0-08-036079-9}}
*{{cite book|last=Page|first=Irvine|title=Chemistry of the brain|year=1937|publisher=C.C. Thomas|location=New York|id=ASIN B-000-87D23-C}}
*Page, Irvine (1972). ''Speaking to the Doctor: His Responsibilities and Opportunities: Selected Editorials from Modern Medicine''. Minneapolis: Proforum.

== Footnotes ==
{{Reflist|2}}

== External links ==

* [http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/page-irvine.pdf Harriet P. Dustan, "Irvine Heinly Page", Biographical Memoirs of the National Academy of Sciences (1995)]
{{Authority control}}{{Cleveland Clinic}}

{{DEFAULTSORT:Page, Irvine}}
[[Category:Cornell University alumni]]
[[Category:American physiologists]]
[[Category:1901 births]]
[[Category:1991 deaths]]
[[Category:Recipients of the Albert Lasker Award for Basic Medical Research]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:20th-century American scientists]]
[[Category:Scientists from Indiana]]
[[Category:People from Indianapolis]]
[[Category:Cleveland Clinic people]]
[[Category:Members of the National Academy of Medicine]]
[[Category:Members of the Royal Swedish Academy of Sciences]]

Irvine Page - Revision history

WikiDwarfBOT at 09:49, 22 July 2023