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{{Short description|Indian medical researcher (born 1957)}}
{{Use dmy dates|date=February 2019}}
{{Use Indian English|date=February 2019}}
{{Infobox scientist
| name = Joyoti Basu
| image =
| alt =
| caption =
| birth_date = {{Birth date and age|df=yes|1957|12|17}}
| birth_place = [[West Bengal]], India
| death_date =
| death_place =
| fields = {{ublist | [[Biochemistry]] | [[Cell biology]] }}
| workplaces = {{ublist | [[Bose Institute]] }}
| alma_mater = {{ublist | [[Presidency college, Calcutta]] | [[Calcutta University]] | [[Bose Institute]] | [[University of Liège]] }}
| doctoral_advisor = {{ublist | Parul Chakrabarti | [[:de:Jean-Marie Ghuysen|Jean-Marie Ghuysen]] }}
| doctoral_students =
| known_for = Studies on interaction of mycobacteria with host macrophages
| awards = {{ublist| 1989 [[Indian National Science Academy|INSA]] Young Scientist Medal | 2002 [[National Bioscience Award for Career Development|N-BIOS Prize]] }}
}}
'''Joyoti Basu''' (born 17 December 1957) is an Indian biochemist, cell biologist and a senior professor at the [[Bose Institute]]. Known for her studies on the membrane structure of [[red blood cells]], Basu is an elected fellow of all three major Indian science academies, namely the [[National Academy of Sciences, India]], the [[Indian Academy of Sciences]] and the [[Indian National Science Academy]], as well as the [[Indian Society for Chemical Biology]]. The [[Department of Biotechnology]] of the Government of India awarded her the [[National Bioscience Award for Career Development]], one of the highest Indian science awards, for her contributions to biosciences in 2002.<ref name="Awardees of National Bioscience Awards for Career Development">{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20 |archive-date=4 March 2018 |archive-url=https://web.archive.org/web/20180304191331/http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |url-status=dead }}</ref>

== Early life and education ==
[[File:Bose Institute - Kolkata 7354.JPG|thumb|left|[[Bose Institute]].]]
[[File:Parul Chakrabarti - Kolkata 2009-11-07 2693.JPG|thumb|Parul Chakrabarti - Basu's mentor at Bose Institute]]
Born on 17 December 1957<ref name="Fellow profile">{{Cite web |url=http://www.ias.ac.in/describe/fellow/Basu,_Dr_Joyoti |title=Fellow profile |date=2017-12-06 |publisher=Indian Academy of Sciences |access-date=2017-12-06}}</ref> in the Indian state of [[West Bengal]], Joyoti Basu did her undergraduate studies at the [[Presidency College, Kolkata]] and after completing the BSc honors in chemistry, she obtained an MSc from the [[University of Calcutta]].<ref name="Indian fellow - Joyoti Basu">{{Cite web |url=http://insaindia.res.in/detail/P09-1475 |title=Indian fellow - Joyoti Basu |date=2017-12-06 |publisher=Indian National Science Academy |access-date=2017-12-06 |archive-date=27 February 2020 |archive-url=https://web.archive.org/web/20200227094739/http://insaindia.res.in/detail/P09-1475 |url-status=dead }}</ref> Her doctoral research was at the [[Bose Institute]], Kolkata<ref name="Joyoti Basu (0000-0002-0497-9581) - ORCID - Connecting Research and Researchers">{{Cite web |url=http://orcid.org/0000-0002-0497-9581 |title=Joyoti Basu (0000-0002-0497-9581) - ORCID |last=ORCID |date=2017-12-09 |website=orcid.org |language=en |access-date=2017-12-09}}</ref><ref name="LIST of Alumni of BOSE INSTITUTE">{{Cite web |url=http://boseinstitutealumni.in/alum.pdf |title=LIST of Alumni of BOSE INSTITUTE |date=2017-12-09 |website=Bose Institute |access-date=2017-12-09 |archive-date=10 December 2017 |archive-url=https://web.archive.org/web/20171210015806/http://boseinstitutealumni.in/alum.pdf |url-status=dead }}</ref> under the guidance of Parul Chakrabarti, which earned her a PhD from Calcutta University. She did her post-doctoral work at the laboratory of Jean-Marie Ghuysen at the [[University of Liège]] working on [[mycobacterial]] cell division and mycobacterial [[peptidoglycan]]-biosynthesizing enzymes. She joined Bose Institute in 1991 as a faculty member at the department of Chemistry.<ref name="Joyoti Basu on Loop">{{Cite web |url=https://loop.frontiersin.org/people/73639/bio |title=Joyoti Basu on Loop |date=2017-12-09 |website=Loop |language=en |access-date=2017-12-09}}</ref><ref name="Joyoti Basu -Bose Institute - Academia.edu">{{Cite web |url=https://boseinst.academia.edu/JoyotiBasu |title=Joyoti Basu -Bose Institute - Academia.edu |date=2017-12-09 |website=boseinst.academia.edu |language=en |access-date=2017-12-09}}</ref>

== Controversy ==
Basu's alleged scientific misconduct has been noted widely and has even been covered in media. She is widely alleged to have duplicated images leading to retraction of two papers, correction of another two, and, many alleged instances of misconduct listed on Pubpeer.<ref name="Image duplication: Group at Bose Institute has two papers retracted, two corrected, and many listed on Pubpeer">{{Cite web |url= https://journosdiary.com/2018/08/09/image-duplication-bose-institute-retracted-corrected-pubpeer/ | title = Image duplication: Group at Bose Institute has two papers retracted, two corrected, and many listed on Pubpeer| date = 2018-08-09}}</ref> Basu has retracted a few of her papers.<ref name="Author objects to retraction for not “faithfully represented” immunology figures">{{Cite web |url=https://retractionwatch.com/2015/10/02/author-objects-to-retraction-for-not-faithfully-represented-immunology-figures/ |title=Author objects to retraction for not "faithfully represented" immunology figures |date=2015-10-02 |website=Retraction Watch |language=en-US |access-date=2018-05-02}}</ref> This includes an article published in [[The Journal of Immunology]].<ref name="Retraction: TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis-, trans-Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages">{{Cite journal |url=https://pubpeer.com/publications/A4594F49CBF5D0D5DA5D717DF53019 |title=Retraction: TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis-, trans-Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages |last1=Basu |first1=Joyoti |last2=Kundu |first2=Manikuntala |date=2015-08-15 |language=en |access-date=2018-05-02}}{{primary source inline|date=October 2025}}</ref><ref name="Retraction: TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis-, trans-Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages 2">{{cite journal |last1=Basu |first1=Joyoti |last2=Kundu |first2=Manikuntala |title=Retraction: TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis -, trans -Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages |journal=The Journal of Immunology |date=15 August 2015 |volume=195 |issue=4 |pages=1902 |doi=10.4049/jimmunol.1501299 |pmid=26473200 |doi-access=free }}{{primary source inline|date=October 2025}}</ref>

== Research work ==
[[File:Blausen 0761 RedBloodCells.png|thumb|180px|Red Blood Cells]]
Basu's research is focused on the cellular and molecular biology of [[mycobacteria]].<ref name="Bose Institute - Joyoti Basu">{{Cite web |url=http://www.jcbose.ac.in/faculty-details/joyoti-basu |title=Bose Institute - Joyoti Basu |date=2017-12-09 |website=www.jcbose.ac.in |access-date=2017-12-09}}</ref> During the initial stages of her career, she worked on the membrane structure of red blood cells and her research is reported to have assisted in widening the understanding of [[apoptosis]] of nucleated mammalian cells and the physiology of the red cell that lacked a cell nucleus.<ref name="Indian fellow - Joyoti Basu" /> Her association with her mentor, Parul Chakrabarti, during her doctoral research days, precipitated the studies of the [[biosynthetic]] pathways of [[fatty acids]] in relation to cell wall building and the functions of [[Penicillin binding proteins|penicillin-binding proteins]].<ref name="BurmaChakravorty2011">{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA247|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=247–}}</ref> She is known to be the first scientist to propose that the removal of the ''aged or [[Oxidative stress|oxidatively stressed]] red blood cells'' from the [[circulatory system]] causes [[cellular death]]. Later she moved on to the biological study of [[Mycobacterium tuberculosis]], a pathogenic bacteria causing [[tuberculosis]], with regard to its host-pathogen interaction and her studies revealed the mechanisms of [[macrophage]] [[apoptosis]] as well as the relationship between host [[cell signaling]] and innate [[immune response]]. In 2007, the team led by Basu and her college mate from the Presidency College, Manikuntala Kundu, were successful in identifying a protein in Mycobacterium tuberculosis which caused weakening of the immune system of the host.<ref name="Hope for a new TB cure, Kolkata scientists identify ‘villain’ protein">{{Cite web |url=http://archive.indianexpress.com/news/hope-for-a-new-tb-cure-kolkata--scientists-identify--villain--protein-/30481/ |title=Hope for a new TB cure, Kolkata scientists identify 'villain' protein |date=9 May 2007 |website=archive.indianexpress.com |language=en-gb |access-date=2017-12-09}}</ref> They found that the protein, named [[ESAT-6|Early Secreted Antigen 6]], which bound themselves on [[Toll-like receptor 2]] of the host, hindered the production of [[cytokines]], a type of protein which helped the immune system to fight the tuberculosis bacteria. The discovery also has reported importance in the [[therapeutics]] of diseases like [[rheumatoid arthritis]].<ref name="Hope for a new TB cure, Kolkata scientists identify ‘villain’ protein" /> The achievement was later published as an article, ''Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages'' in [[Nature Immunology]] journal in 2007.<ref>{{Cite journal |last1=Pathak |first1=Sushil Kumar |last2=Basu |first2=Sanchita |last3=Basu |first3=Kunal Kumar |last4=Banerjee |first4=Anirban |last5=Pathak |first5=Shresh |last6=Bhattacharyya |first6=Asima |last7=Kaisho |first7=Tsuneyasu |last8=Kundu |first8=Manikuntala |last9=Basu |first9=Joyoti |date=June 2007 |title=Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages |journal=Nature Immunology |volume=8 |issue=6 |pages=610–618 |doi=10.1038/ni1468 |pmid=17486091 }}{{primary source inline|date=October 2025}}</ref> Her studies have been documented by way of a number of articles<ref name="Browse by Fellow">{{Cite web |url=http://repository.ias.ac.in/view/fellows/Basu=3AJoyoti=3A=3A.html |title=Browse by Fellow |date=2017-12-06 |publisher=Indian Academy of Sciences |access-date=2017-12-06}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} and [[ResearchGate]], an online repository of scientific articles has listed 77 of them.<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/profile/Joyoti_Basu |title=On ResearchGate |date=2017-11-23 |access-date=2017-11-23}}</ref> Besides, she has mentored several research scholars in their doctoral studies.<ref name="Junior Research Fellow">{{Cite web |url=http://www.iisc.ernet.in/currsci/sep252006/847.pdf |title=Junior Research Fellow |date=2006 |website=Indian Institute of Science |access-date=2017-12-09}}</ref>

Basu is a member of the executive committee of the Indian Society of Cell Biology<ref name="EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY">{{Cite web |url=http://www.iscb.org.in/present_ec.htm |title=EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY |date=2017-12-09 |website=www.iscb.org.in |access-date=2017-12-09}}</ref> and is a former Treasurer of the Society.<ref name="EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY 2003-05">{{Cite web |url=http://www.iscb.org.in/2003-05.htm |title=EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY 2003-05 |website=www.iscb.org.in |access-date=2017-12-09}}</ref><ref name="EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY 2005-07">{{Cite web |url=http://www.iscb.org.in/2005-07.htm |title=EXECUTIVE COMMITTEE MEMBERS OF THE SOCIETY 2005-07 |website=www.iscb.org.in |access-date=2017-12-09}}</ref> She is credited with contributing to the establishment of a program on ''Systems Biology'' at the Bose Institute. She is also a former associate editor of the [[Journal of Immunology]] and is an Academic Editor of [[PLOS One|PLoS One]].<ref name="Indian fellow - Joyoti Basu" />

Basu retired in June 2018.
Basu resides on Madhab Chatterjee Street in [[Kolkata]].<ref name="NASI fellows">{{Cite web |date=2017-11-12 |title=NASI fellows |url=http://www.nasi.org.in/fellows.asp?RsFilter=B |url-status=dead |archive-url=https://web.archive.org/web/20150717005033/http://www.nasi.org.in/fellows.asp?RsFilter=B |archive-date=17 July 2015 |access-date=2017-11-12 |publisher=National Academy of Sciences, India}}</ref>

== Awards and honors ==
Basu received the Young Scientist Medal of the [[Indian National Science Academy]] in 1989.<ref name="INSA Young Scientists Medal">{{Cite web |url=http://insaindia.res.in/youngmedal.php |title=INSA Young Scientists Medal |date=2017-11-12 |publisher=Indian National Science Academy |access-date=2017-11-12 |archive-date=11 May 2021 |archive-url=https://web.archive.org/web/20210511084357/https://www.insaindia.res.in/youngmedal.php |url-status=dead }}</ref> The [[Department of Biotechnology]] of the Government of India awarded her the [[National Bioscience Award for Career Development]], one of the highest Indian science awards in 2002.<ref name="Awardees of National Bioscience Awards for Career Development" /> The [[National Academy of Sciences, India]] elected her as a fellow the same year.<ref name="NASI Year Book 2015">{{Cite web |url=http://www.nasi.org.in/Year%20Book%202015.pdf |title=NASI Year Book 2015 |date=2017-11-24 |publisher=National Academy of Sciences, India |access-date=2017-11-24 |archive-date=6 August 2015 |archive-url=https://web.archive.org/web/20150806211716/http://www.nasi.org.in/Year%20Book%202015.pdf |url-status=dead }}</ref> She received the elected fellowships of the [[Indian Academy of Sciences]] and the Indian National Academy of Sciences in 2006<ref name="Fellow profile" /> and 2009 respectively.<ref name="INSA Year Book 2016">{{Cite web |url=http://www.insaindia.res.in/pdf/YearBook_2016.pdf |title=INSA Year Book 2016 |date=2017-12-09 |publisher=Indian National Science Academy |access-date=2017-12-09 |archive-url=https://web.archive.org/web/20161104001952/http://www.insaindia.res.in/pdf/YearBook_2016.pdf |archive-date=4 November 2016 |url-status=dead }}</ref> She is a recipient of the J.C. Bose National Fellowship in 2017.

== Selected bibliography ==
* {{cite journal |last1=Kumawat |first1=Kuldeep |last2=Pathak |first2=Sushil Kumar |last3=Spetz |first3=Anna-Lena |last4=Kundu |first4=Manikuntala |last5=Basu |first5=Joyoti |title=Exogenous Nef Is an Inhibitor of Mycobacterium tuberculosis-induced Tumor Necrosis Factor-α Production and Macrophage Apoptosis |journal=Journal of Biological Chemistry |date=April 2010 |volume=285 |issue=17 |pages=12629–12637 |doi=10.1074/jbc.m109.073320 |pmid=20068037 |pmc=4705387 |doi-access=free }}
* {{cite journal |last1=Sureka |first1=Kamakshi |last2=Sanyal |first2=Sourav |last3=Basu |first3=Joyoti |last4=Kundu |first4=Manikuntala |title=Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria |journal=Molecular Microbiology |date=December 2009 |volume=74 |issue=5 |pages=1187–1197 |doi=10.1111/j.1365-2958.2009.06925.x |pmid=19843229 |doi-access=free }}
* {{cite journal |last1=Basu |first1=Sanchita |last2=Pathak |first2=Shresh |last3=Pathak |first3=Sushil Kumar |last4=Bhattacharyya |first4=Asima |last5=Banerjee |first5=Anirban |last6=Kundu |first6=Manikuntala |last7=Basu |first7=Joyoti |title=Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification: Mycobacterium avium-induced MMP-9 expression |journal=Cellular Microbiology |date=December 2007 |volume=9 |issue=12 |pages=2804–2816 |doi=10.1111/j.1462-5822.2007.00997.x |pmid=17590163 |doi-access=free }}

== See also ==
{{Div col|colwidth=30em}}
* [[ESAT-6]]
* [[Host–pathogen interaction]]
{{div col end}}
{{portal|India|Biology}}

== Notes ==
{{reflist|group=note|2}}

== References ==
{{reflist}}

{{authority control}}
{{N-BIOS Laureates 1999–2009}}

{{DEFAULTSORT:Basu, Joyoti}}
[[Category:N-BIOS Prize recipients]]
[[Category:Indian women academics]]
[[Category:Fellows of the National Academy of Sciences, India]]
[[Category:1957 births]]
[[Category:Living people]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:Women scientists from West Bengal]]
[[Category:Indian biochemists]]
[[Category:University of Calcutta alumni]]
[[Category:University of Liège alumni]]
[[Category:Indian cell biologists]]
[[Category:Scientists from Kolkata]]
[[Category:20th-century Indian biologists]]
[[Category:20th-century Indian women scientists]]

Joyoti Basu - Revision history

AgnesOppen5 at 23:08, 7 February 2026