https://indianpedia.org/index.php?action=history&feed=atom&title=Kuppamuthu_DharmalingamKuppamuthu Dharmalingam - Revision history2026-07-31T11:08:46ZRevision history for this page on the wikiMediaWiki 1.45.4https://indianpedia.org/index.php?title=Kuppamuthu_Dharmalingam&diff=115079&oldid=prev>Monkbot at 17:54, 2 January 20212021-01-02T17:54:43Z<p></p>
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{{Infobox scientist<br />
| name = Kuppamuthu Dharmalingam<br />
| image = <br />
| alt = <br />
| caption = <br />
| birth_date = {{Birth date and age|df=yes|1949|1|3}}<br />
| birth_place = [[Pollachi]], [[Tamil Nadu]], India<br />
| death_date = <br />
| death_place = <br />
| residence = [[Madurai]], Tamil Nadu, India<br />
| nationality = [[Indian nationality|Indian]]<br />
| fields = {{ublist | [[Molecular genetics]] | [[Genetic engineering]] }}<br />
| workplaces = {{ublist | [[Madurai Kamaraj University]] | Aravind Medical Research Foundation }}<br />
| alma_mater = {{ublist | Gandhi Kala Nilayam High School] | Thiagarajar College, Madurai | [[Madurai Kamaraj University]] | [[Tufts University School of Medicine]] }}<br />
| doctoral_advisor = J. Jayaraman<br />
| doctoral_students = <br />
| known_for = Induction of [[mutagenic]] DNA repair in [[Escherichia coli]]<br>[[Proteomics]] of eye diseases<br />
| awards = 1992&nbsp;[[Shanti Swarup Bhatnagar Prize]]<br />
}}<br />
<br />
'''Kuppamuthu Dharmalingam''' (born 3 January 1949) is an Indian [[Proteomics|proteomicist]], geneticist, academic and the founder of ''Centre of Excellence in Bioinformatics'' at [[Madurai Kamaraj University]]. He is known for his contributions in the fields of eye disease [[proteomics]] and [[mutagenic]] DNA repair in [[Escherichia coli]].<ref name="Brief Profile of the Awardee">{{cite web | url=http://ssbprize.gov.in/content/Detail.aspx?AID=448 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is an elected fellow of the [[Indian Academy of Sciences]]<ref name="Fellow profile - Dharmalingam">{{cite web | url=http://www.ias.ac.in/describe/fellow/Dharmalingam,_Prof._Kuppamuthu | title=Fellow profile - Dharmalingam | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}}</ref> and the [[National Academy of Sciences, India]].<ref name="NASI fellows">{{cite web|url=http://www.nasi.org.in/fellows.asp?RsFilter=D |title=NASI fellows |publisher=National Academy of Sciences, India |date=2016 |access-date=6 October 2016 |url-status=dead |archive-url=https://web.archive.org/web/20150717020647/http://www.nasi.org.in/fellows.asp?RsFilter=D |archive-date=17 July 2015 }}</ref> The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards, in 1992, for his contributions to biological sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref><br />
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== Biography ==<br />
Born on 3 January 1949 in [[Pollachi]], a border town in the [[South India]]n state of [[Tamil Nadu]], Kuppamuthu Dharmalingam did his schooling at Gandhi Kala Nilayam High School and secured his graduate and master's degrees in zoology from Thiagarajar College, [[Madurai]] before enrolling for PhD at [[Madurai Kamaraj University]] (MKU) under the guidance of J. Jayaraman, working on ''yeast mitochondrial membrane [[biogenesis]]''.{{cn|date=November 2019}} After obtaining his doctoral degree, he did his post-doctoral research with [[Edward D. Goldberg]] at [[Tufts University School of Medicine]] on [[genetics]] of [[bacteriophages]]. Returning to India, he joined MKU<ref name="Murphy2011">{{cite book|author=Michael J. Murphy|title=Molecular Diagnostics in Dermatology and Dermatopathology|url=https://books.google.com/books?id=cyDyIqkmJAMC&pg=PA347|date=24 March 2011|publisher=Springer Science & Business Media|isbn=978-1-60761-171-4|pages=347–}}</ref> and spent his entire academic career there but had a short stint at [[University of Geneva]] in between. During his early researches on [[Escherichia coli]], a [[gram-negative]] bacterium, he discovered the ''induction of mutagenic DNA repair during restriction of nonglucosylated T4 DNA'' and the ''alleviation of restriction by SOS functions''.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=30 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }}</ref> Subsequently, he studied the [[pathogenesis]] of [[Mycobacterium leprae]] using [[proteomics]] tools and discovered the ''single nucleotide polymorphism in the unique small alpha crystalline like heat shock protein'' in the [[gram-positive]] bacterium.<ref name="Functional insights by comparison of modeled structures of 18kDa small heat shock protein and its mutant in Mycobacterium leprae">{{cite journal | title=Functional insights by comparison of modeled structures of 18kDa small heat shock protein and its mutant in Mycobacterium leprae | author=Rehna EA1, Singh SK, Dharmalingam K. | journal=Bioinformation | year=2008 | volume=3 | issue=5 | pages=230–4 | pmid=19255639 | doi=10.6026/97320630003230 | pmc=2646194}}</ref> His researches have been documented in over 200 articles; [[ResearchGate]], an online repository of scientific papers, has listed 48 of them.<ref name="Kuppamuthu Dharmalingam on ResearchGate">{{cite web | url=https://www.researchgate.net/profile/Kuppamuthu_Dharmalingam | title=Kuppamuthu Dharmalingam on ResearchGate | date=2016 | access-date=6 October 2016}}</ref><br />
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It was during his tenure at the MKU, the ''Centre of Excellence in Bioinformatics'' was established at the university in 1986.{{cn|date=November 2019}} He is a life member of the Proteomics Society, India (PSI),<ref name="Life members">{{cite web | url=http://www.psindia.org/members.html | title=Life members | publisher=Proteomics Society, India | date=2016 | access-date=6 October 2016}}</ref> editor of its newsletter,<ref name="PSII News Letter">{{cite web | url=http://www.psindia.org/images/psi_news_letter_vol_4_no_2.pdf | title=PSII News Letter | publisher=Proteomics Society, India | date=2016 | access-date=6 October 2016}}</ref> a former member of its executive council and was the convener of the workshop, ''Clinical Proteomics: Methods and Applications'', conducted by PSI in October 2014.<ref name="Clinical Proteomics: Methods and Applications">{{cite web | url=http://www.psindia.org/images/psi_news_letter_vol_2_no_3.pdf | title=Clinical Proteomics: Methods and Applications | publisher=PSi Newsletter | date=2016 | access-date=6 October 2016}}</ref> He is a Distinguished Research Professor of the [[Department of Biotechnology]] and an elected fellow of the [[Indian Academy of Sciences]]<ref name="Fellow profile - Dharmalingam" /> and the [[National Academy of Sciences, India]].<ref name="NASI fellows" /> The [[Council of Scientific and Industrial Research]] awarded him the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards, in 1992.<ref name="View Bhatnagar Awardees" /><br />
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Post retirement, Dharmalingam has been working since 2013 as a director of Aravind Medical Research Foundation, a Tamil Nadu-based research centre, ophthalmic hospital chain and a [[World Health Organization]] collaborating centre for the prevention of blindness.<ref name="Director & DBT Distinguished Biotechnology Research">{{cite web | url=http://www.aravind.org/default/researchnewcontent/faculty | title=Director & DBT Distinguished Biotechnology Research | publisher=Aravind Eye Care System | date=2016 | access-date=6 October 2016}}</ref><br />
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== See also ==<br />
* [[Proteomics]]<br />
* [[Edward D. Goldberg]]<br />
{{portal|India|Biology}}<br />
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== References ==<br />
{{reflist}}<br />
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== External links ==<br />
* {{cite web | url=http://www.aravind.org/default/researchnewcontent/profile_dharmalingam | title=DR. K. DHARMALINGAM - Director Research | publisher=Aravind Eye Care System | work=Director profile | date=2016 | access-date=6 October 2016}}<br />
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{{SSBPST recipients in Biological Science}}<br />
{{Shanti Swarup Bhatnagar Laureates of Tamil Nadu}}<br />
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{{DEFAULTSORT:Dharmalingam, Kuppamuthu}}<br />
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Biological Science]]<br />
[[Category:1949 births]]<br />
[[Category:People from Coimbatore district]]<br />
[[Category:Tamil scientists]]<br />
[[Category:Indian geneticists]]<br />
[[Category:Proteomics]]<br />
[[Category:Indian scientific authors]]<br />
[[Category:Madurai Kamaraj University alumni]]<br />
[[Category:Tufts University School of Medicine alumni]]<br />
[[Category:University of Geneva alumni]]<br />
[[Category:Fellows of the Indian Academy of Sciences]]<br />
[[Category:Fellows of The National Academy of Sciences, India]]<br />
[[Category:Living people]]<br />
[[Category:20th-century Indian biologists]]<br />
[[Category:Scientists from Madurai]]</div>>Monkbot