Dipyaman Ganguly

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Template:Infobox scientist Dipyaman Ganguly is an Indian physician-scientist immunologist and cell biologist, currently a professor in the Department of Biology, Ashoka University.[1] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2022.

Ganguly graduated in medicine from Medical College and Hospital, Kolkata in 2001 but shifted his focus to biomedical research and joined the Institute of Genomics and Integrative Biology as a clinical associate.[1] In 2003, he joined Indian Institute of Chemical Biology for doctoral research as a research scholar which earned him his first PhD in 2006. Moving to the US, he carried on his research at University of Texas MD Anderson Cancer Center and received another PhD from the University of Texas Health Science Center at Houston.[2] His post-doctoral work was at the Columbia University Medical Center as an SLE Foundation Fellow[3] He was also a Swarnajayanti Fellow of the Department of Science and Technology, and was formerly a Ramanujan Fellow of the Science and Engineering Research Board of the Department of Science and Technology.

Scientific contribution

Research interests of Ganguly lab are exploring the role of dendritic cells in autoreactive inflammatory contexts, deciphering molecular regulation of innate immune response and exploring the role of mechanical cues in immune cells. Researchers from Ganguly Lab recently discovered a novel regulatory module involving the Piezo1 mechanosensors in human T cells, driven by mechanical cues.[4] They also provided the first evidence for involvement of plasmacytoid dendritic cells in obesity and associated metabolic syndrome in humans.[5][6] Previous work by Dipyaman Ganguly led to discovery of the key initiation events in pathogenesis of the skin autoimmunity in Psoriasis,[7] as well as first identification of dying neutrophils as the major source of nuclear antigens in systemic lupus,[8] which was featured in Nature Reviews Key Advances in Medicine for the year 2012. Ganguly lab has also interest in development of new therapies for autoimmune diseases.[9] Ganguly lab also took interest in performing research on immunology of COVID-19 disease and ran a randomized control trial on convalescent plasma therapy.[10]

Awards

The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18.[11] He is also a recipient of the Merck Young Scientist Award, the CDRI Award for Excellence in Drug Research from CSIR-Central Drug Research Institute, Swarnajayanthi Fellowship of the Department of Science and Technology and the NASI-Scopus Young Scientist Award of the Elsevier.[12] He was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology in Medical Sciences in the year 2022.

Public outreach

Ganguly is an enthusiast for public outreach of science in India,[13][14] an avid stargazer and a public commentator and popular columnist on issues on science and health.[15][16][17][18][19][20][21][22]

Selected bibliography

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  • Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. The Journal of Experimental Medicine({Template:Date).
  • Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Science Translational Medicine({Template:Date).
  • Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype. Journal of Immunology({Template:Date).
  • Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. Journal of Immunology({Template:Date).
  • Do Type I Interferons Link Systemic Autoimmunities and Metabolic Syndrome in a Pathogenetic Continuum?. Trends in Immunology({Template:Date).
  • Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation. Diabetes({Template:Date).
  • T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nature Immunology({Template:Date).
  • The role of dendritic cells in autoimmunity. Nature Reviews Immunology({Template:Date).
  • Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. The Journal of Experimental Medicine({Template:Date).
  • A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist. Journal of Medicinal Chemistry({Template:Date).

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See also

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Notes

  1. ↑ 1.0 1.1 Profile on SERB. Scientific and Engineering Research Board(2018-12-27). Retrieved 2018-12-27.
  2. ↑ IICB profile. Indian Institute of Chemical Biology(2018-12-27). Retrieved 2018-12-27.
  3. ↑ S.L.E. Lupus Foundation announces new grants to further NYC scientists' leadership in lupus research.. EurekAlert!. Retrieved 2019-07-10.
  4. ↑ Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. The Journal of Immunology({Template:Date).
  5. ↑ Why the obese are prone to diabetes: a protein gives a clue. The Indian Express(2016-09-26). Retrieved 2019-07-10.
  6. ↑ Obesity link to diabetes decoded. www.telegraphindia.com. Retrieved 2019-07-10.
  7. ↑ Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. The Journal of Experimental Medicine({Template:Date).
  8. ↑ Systemic Lupus Erythematosus and the Neutrophil. New England Journal of Medicine({Template:Date).
  9. ↑ IICB Scientists Aiming at First-in-Class Drugs for Autoimmune Diseases. BioTech Times(2018-06-03). Retrieved 2019-07-10.
  10. ↑ A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19. Nature Communications({Template:Date).
  11. ↑ Awardees of National Bioscience Awards for Career Development. Department of Biotechnology(2016). Retrieved 2017-11-20.
  12. ↑ Scopus Award 2017. southasia.elsevier.com(2018-12-27). Retrieved 2018-12-27.
  13. ↑ DIALOGUE - Science, Scientists, and Society. Dialogue. Retrieved 2019-07-10.
  14. ↑ Are we reaching the 'public' with our public outreach programs?. IndiaBioscience(2018-07-13). Retrieved 2019-07-10.
  15. ↑ Coronavirus: the fight & the soldiers.
  16. ↑ Preparing for long-lasting Covid.
  17. ↑ One pandemic unmasking another.
  18. ↑ Will the vaccines protect us from new strains of the novel coronavirus?.
  19. ↑ More 'strain' on Covid management(12 January 2021).
  20. ↑ Slow mutation of the Covid pandemic(9 February 2021).
  21. ↑ Pandemic will end up as an endemic(21 April 2021).
  22. ↑ Herd immunity may come before COVID-19 vaccine(26 July 2020).

References

Template:N-BIOS Laureates 2010–2019

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